Cat. No. |
Product Name |
Information |
PC-20815 |
MHV370
TLR7/8 inhibitor
|
MHV370 (MHV-370) is a potent, selective, orally bioavailable inhibitor of Toll-like receptors 7 and 8 (TLR7/8) with IC50 of 1.1 and 4.5 nM in cell-based assays. |
PC-49254 |
GS-9620
TLR7 agonist
|
Vesatolimod (GS-9620) is a potent and selective orally active small molecule agonist of Toll-like receptor 7 (TLR7) with EC50 of 291 nM. |
PC-49146 |
SZU-106
TLR7 agonist
|
SZU-106 is a small molecule TLR7 agonist, selectively activates TLR7 and increases the expression of SEAP by activating the NF-κB pathway. |
PC-49145 |
SZU-101
TLR7 agonist
|
SZU101 is a small molecule TLR7 agonist that directly activates, induces reporter activity (23-fold) in a TLR7-NF-kB reporter system expressed in HEK-293 cells TLR7 signalling. |
PC-49127 |
E567
TLR2 inhibitor
|
E567 is a small moleculeTLR2 signaling inhibitor with anti-viral activity, efficiently inhibits both LCMV and HSV-1 induced cytokine responses in both human and mouse cell cultures. |
PC-49018 |
SMU-Z1
TLR1/2 agonist
|
SMU-Z1 is a potent, specific small molecule agonist of TLR1/2, specifically activates TLR2 through its association with TLR1, induces NF‐κB activation in HEK‐Blue hTLR2 cells with EC50 of 4.88 nM. |
PC-38678 |
Guretolimod
TLR7 agonist
|
Guretolimod (DSP-0509) is a potent, selective Toll-like receptor 7 (TLR7) agonist with EC50 of 515 nM and 33 nM for human and murine TLR7 respectively, shows no agonistic activity against TLR8. |
PC-73063 |
1V209
TLR7 agonist
|
1V209 is a synthetic small molecule TLR7 specific ligand and agonist. |
PC-72050 |
SM360320
TLR7 agonist
|
SM360320 (CL-087, 1V136) is a potent, orally active and selective TLR7 agonist (ligand). |
PC-72049 |
M5049
TLR7/8 inhibitor
|
M5049 (Enpatoran, M-5049) is a novel potent, selective TLR7/8 inhibitor with IC50 of 11.1/24.1 nM in HEK NF-kB-luciferase reporter cells assay, repectively |
PC-38135 |
CU-CPT22
TLR1/TLR2 inhibitor
|
CU-CPT22 is a specific small-molecule inhibitor of the TLR1/TLR2 complex with IC50 of 0.58 uM (NO production in RAW 264.7 cells). |
PC-38134 |
MMG-11
TLR2 inhibitor
|
MMG-11 (MMG11) is a potent and selective TLR2 antagonist with pA2 values of 5.73 and 6.15 (TLR2/1), preferentially inhibits TLR2/1 signaling. |