| Cat. No. |
Product Name |
Information |
| PC-21818 |
DSP-0509
TLR7 agonist
|
DSP-0509 (DSP0509) is a potent selective small-molecule TLR7 agonist with EC50 of 515 nM and 33 nM in cells expressing human and murine TLR7, respectively. |
| PC-21372 |
TH1020
TLR5 antagonist
|
TH1020 is a potent, selective antagonist of TLR5/flagellin protein-protein interaction with IC50 of 0.85 uM. |
| PC-21010 |
E6742
TLR7/TLR8 inhibitor
|
E6742 (E6742) is a potent, selective, dual TLR7/8 inhibitor with binding Kd of 1.7 uM/37 nM in ITC assays, respectively, inhibits TLR7/8 agonist CL097 induced reporter activation with IC50 values of 22, 68, and 3.0 nM for hTLR7, mTLR7, and hTLR8, respectively. |
| PC-20815 |
MHV370
TLR7/8 inhibitor
|
MHV370 (MHV-370) is a potent, selective, orally bioavailable inhibitor of Toll-like receptors 7 and 8 (TLR7/8) with IC50 of 1.1 and 4.5 nM in cell-based assays. |
| PC-20737 |
Neoseptin-3
TLR4/MD2 agonist
|
Neoseptin-3 is a specific synthetic agonist of mouse toll-like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD-2) complex, promotes macrophage TNFα production with EC50 of 18.5 uM. |
| PC-20350 |
Pam3CSK4 TFA
TLR2 agonist
|
Pam3CSK4 (Pam3CysSerLys4) is a synthetic triacylated lipopeptide and a TLR2 agonist, a potent activator of the pro-inflammatory transcription factor NF-κB, mimics the acylated amino terminus of bacterial LPs. |
| PC-20234 |
Imiquimod
TLR7 agonist
|
Imiquimod (Aldara,R-837,S-26308) is a small molecule TLR7 agonist, activates toll-like receptor 7 (EC50=2.1 μM) on immune cells and also enables an OGF-mediated block of cell proliferation (IC50=2 uM). |
| PC-20233 |
Gardiquimod diTFA
TLR7 agonist
|
Gardiquimod diTFA is a small molecule agonist of TLR7 but not of human TLR8, activates both porcine TLR7 and TLR8. |
| PC-20232 |
Gardiquimod
TLR7 agonist
|
Gardiquimod is a small molecule agonist of TLR7 but not of human TLR8, activates both porcine TLR7 and TLR8. |
| PC-20231 |
CU-CPT17e
TLR agonist
|
CU-CPT17e is a multi-TLR agonist withEC50 of 4.8 μM, 13.4 μM and 5.7 μM for strong NF-κB activation on hTLR 3, 8 and 9 respectively. |
| PC-20230 |
R848
TLR7/8 agonist
|
Resiquimod (R848) is a potent, dual TLR8 and TLR7 synthetic agonist, induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α, demonstrates potent anti-tumor and anti-viral properties. |
| PC-20229 |
AZD8848
TLR7 agonist
|
AZD8848 (AZD 8848) is a potent, selective TLR7 agonist with EC50 of 4 nM for induction of IFNα from human PBMCs and an IC50 of 0.2-1.0 nM for inhibition of IL-5. |
