Chemical Structure : BXY-14
CAS No.:
BXY-14
(BXY14)
Catalog No.: PC-26302Not For Human Use, Lab Use Only.
BXY-14 is a highly potent TLR2 agonist, stimulates TNF-α release with EC50 of 2.2 nM and 1.8 nM in human THP-1 cells and mBMDCs respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BXY-14 is a highly potent TLR2 agonist, stimulates TNF-α release with EC50 of 2.2 nM and 1.8 nM in human THP-1 cells and mBMDCs respectively.
BXY-14 exhibited slightly stronger TLR2-activating activity than Diprovocim in hPBMCs, with EC50 values of 0.58 nM.
BXY-14 at 10 mg/kg induced stronger total IgG, IgG1, and IgG2c responses compared to Diprovocim in C57BL/6J mice.
At 10 mg/kg, BXY-14 in combination with the anti-PD-L1 antibody atezolizumab exhibited stronger tumor growth inhibition than Diprovocim.
BXY-14 monotherapy (20 mg/kg) potently suppressed tumor growth and prolonged survival, mechanistically linked to its downregulation of PD-L1 in tumors.
Physicochemical Properties
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M.Wt
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646.90
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Formula
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C35H66O10
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-3-(((2R,3R,4R,5S)-3,4-Dihydroxy-5-((R)-1-hydroxy-2-(tridecanoyloxy)ethyl)tetrahydrofuran-2-yl)oxy)-2-hydroxypropyl Tridecanoate
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References
1. Hongbin Jia, et al. J Med Chem. 2026 Mar 1. doi: 10.1021/acs.jmedchem.5c03709.
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