PVP-057 | TLR3 agonist | Probechem Biochemicals

Chemical Structure : PVP-057

PVP-057 (PVP507)

Catalog No.: PC-26179Not For Human Use, Lab Use Only.

PVP-057 is a specific small molecule Toll-like receptor 3 (TLR3) agonist, activates TLR3-dependent IRF and NF-kB signaling.

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Biological Activity

PVP-057 is a specific small molecule Toll-like receptor 3 (TLR3) agonist, activates TLR3-dependent IRF and NF-kB signaling.
PVP-057 induces strong IRF-driven immunomodulation with minimal cellular toxicity with minimal cellular toxicity.
PVP-057 (10 uM) demonstrates robust activation of HEK-hTLR3 cells at levels comparable to 1 µg/mL poly(I:C).
PVP-057 demonstrates robust in vivo adjuvanticity, amplifies cellular immunity.

Physicochemical Properties

M.Wt	498.57
Formula	C23H22N4O5S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(2-((6-ethoxybenzo[d]thiazol-2-yl)amino)-2-oxoethyl)thiazol-2-yl)-3,5-dimethoxybenzamide

References

1. Lee B, et al. Nat Commun. 2025 Dec 4;17(1):364.

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PVP-057 (PVP507)

Biological Activity

Physicochemical Properties

References

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