| Cat. No. |
Product Name |
Information |
| PC-22582 |
PVP-037
TLR7/8 agonist
|
PVP-037 is a small-molecule that induces cytokine production, demonstrates TLR7-dependent enhancement of TH1-polarizing adjuvanticity. |
| PC-22146 |
E6446 dihydrochloride
TLR7/TLR9 inhibitor
|
E6446 dihydrochloride is a potent, orally available small molecule inhibitor of TLR7 and TLR9 with IC50 of 1.78 uM and 0.01 uM, respectively. |
| PC-22025 |
GY101
TLR7 agonist
|
GY101 is a potent, selective TLR7 agonist, activates the TLR7/NF-κB signaling pathway with EC50 of 0.15 uM. |
| PC-21750 |
TLR7 agonist 20
TLR7 agonist
|
TLR7 agonist 20 is a potent, selective TLR7 agonist with EC50 of 12 nM and 17 nM for hTLR and mTLR7 in cell-based reporter assay, respectively. |
| PC-21155 |
E104
TLR7 agonist
|
E014 is a potent, selective TLR7 agonist with EC50 of 69 nM in Ramos Blue reporter assays, >500-fold selective for TLR7 over TLR8. |
| PC-21154 |
TLR7 agonist 17b
TLR7 agonist
|
TLR7 agonist 17b is a potent, selective TLR7 agonist with EC50 of 18 nM in Ramos Blue reporter assays, >500-fold selective for TLR7 over TLR8. |
| PC-21103 |
Loxoribine
TLR7 agonist
|
Loxoribine (7-Allyl-8-oxoguanosine, RWJ21757) is a selective Toll-like receptor 7 (TLR7) agonist and immune modulator. |
| PC-20350 |
Pam3CSK4
TLR2 agonist
|
Pam3CSK4 (Pam3CysSerLys4) is a synthetic triacylated lipopeptide and a TLR2 agonist, a potent activator of the pro-inflammatory transcription factor NF-κB, mimics the acylated amino terminus of bacterial LPs. |
| PC-20234 |
Imiquimod
TLR7 agonist
|
Imiquimod (Aldara,R-837,S-26308) is a small molecule TLR7 agonist, activates toll-like receptor 7 (EC50=2.1 μM) on immune cells and also enables an OGF-mediated block of cell proliferation (IC50=2 uM). |
| PC-20233 |
Gardiquimod diTFA
TLR7 agonist
|
Gardiquimod diTFA is a small molecule agonist of TLR7 but not of human TLR8, activates both porcine TLR7 and TLR8. |
| PC-20232 |
Gardiquimod
TLR7 agonist
|
Gardiquimod is a small molecule agonist of TLR7 but not of human TLR8, activates both porcine TLR7 and TLR8. |
| PC-20227 |
Motolimod
TLR8 agonist
|
Motolimod (VTX-2337) is a potent, selective small-molecule TLR8 agonist, stimulates PBMCs to produce TNFα and IL-12 with EC50 of 140 and 120 nM, respectively. |
