| Cat. No. |
Product Name |
Information |
| PC-20350 |
Pam3CSK4
TLR2 agonist
|
Pam3CSK4 (Pam3CysSerLys4) is a synthetic triacylated lipopeptide and a TLR2 agonist, a potent activator of the pro-inflammatory transcription factor NF-κB, mimics the acylated amino terminus of bacterial LPs. |
| PC-20234 |
Imiquimod
TLR7 agonist
|
Imiquimod (Aldara,R-837,S-26308) is a small molecule TLR7 agonist, activates toll-like receptor 7 (EC50=2.1 μM) on immune cells and also enables an OGF-mediated block of cell proliferation (IC50=2 uM). |
| PC-20233 |
Gardiquimod diTFA
TLR7 agonist
|
Gardiquimod diTFA is a small molecule agonist of TLR7 but not of human TLR8, activates both porcine TLR7 and TLR8. |
| PC-20232 |
Gardiquimod
TLR7 agonist
|
Gardiquimod is a small molecule agonist of TLR7 but not of human TLR8, activates both porcine TLR7 and TLR8. |
| PC-20230 |
R-848
TLR7/8 agonist
|
Resiquimod (R848) is a potent, dual TLR8 and TLR7 synthetic agonist, demonstrates potent anti-tumor and anti-viral properties. |
| PC-20227 |
Motolimod
TLR8 agonist
|
Motolimod (VTX-2337) is a potent, selective small-molecule TLR8 agonist, stimulates PBMCs to produce TNFα and IL-12 with EC50 of 140 and 120 nM, respectively. |
| PC-20180 |
TLR3-dsRNA complex inhibitor
TLR3 inhibitor
|
TLR3/dsRNA Complex Inhibitor (CU-CPT4a, TLR3i) is a specific small molecule inhibitor targeting the dsRNA binding region of TLR3 with Ki of 2.96 uM, blocks Poly (I:C)-induced TLR3 activation with IC50 of 3.44 uM. |
| PC-73460 |
Polvitolimod
TLR7 agonist
|
Polvitolimod is a toll-like receptor 7 (TLR7) agonist for treatment of cancer and infectious disease. |
| PC-73443 |
Ruzotolimod
TLR7 agonist
|
Ruzotolimod (RO7020531) is a potent, selective, oral TLR7 agonist in clinical development as part of a curative regimen against chronic hepatitis B. |
| PC-73105 |
CU-72
TLR7/8 inhibitor
|
CU-72 is a potent, selective TLR7/8 dual inhibitor with IC50 of 5.10 and 2.87 uM, respectively. |
| PC-72474 |
BMS-986256
TLR7/8 inhibitor
|
BMS-986256 (Afimetoran, BMS986256) is an orally active, potent and selective inhibitor antagonist of TLR7/8. |
| PC-72053 |
CU-CPD107
TLR8 modulator
|
CU-CPD107 is a TLR8-specific small molecule with unique synergistic agonist activities in the presence of ssRNA, but inactive without the aid of ssRNA. |
