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Chemical Structure : PF-4878691
CAS No.: 532959-63-0
Catalog No.: PC-70303Not For Human Use, Lab Use Only.
PF-4878691 (PF-04878691, S32865, 3M-852A) is a selective TLR7 agonist that potently induces IFN-α and IFN-regulated proteins from human PBMC.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | $558 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PF-4878691 (PF-04878691, S32865, 3M-852A) is a selective TLR7 agonist that potently induces IFN-α and IFN-regulated proteins from human PBMC.
PF 04878691 up-regulates the expression of CD83, CD86, and CD38 in IFN-beta-primed DC but not in immature DC.
PF 04878691 induces significantly less pDC maturation in cells from HIV+ individuals;
| M.Wt | 361.46 | |
| Formula | C17H23N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-[4-(4-Amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]methanesulfonamide |
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1. Severa M, et al. J Immunol. 2007 May 15;178(10):6208-16.
2. Gorden KK, et al. J Immunol. 2006 Dec 1;177(11):8164-70.
3. Martinson JA, et al. Cell Immunol. 2007 Nov-Dec;250(1-2):75-84.
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