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PF-4878691

Chemical Structure : PF-4878691

CAS No.: 532959-63-0

PF-4878691 (PF-04878691;PF 4878691;S 32865;3M-852A)

Catalog No.: PC-70303Not For Human Use, Lab Use Only.

PF-4878691 (PF-04878691, S32865, 3M-852A) is a selective TLR7 agonist that potently induces IFN-α and IFN-regulated proteins from human PBMC.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-4878691 (PF-04878691, S32865, 3M-852A) is a selective TLR7 agonist that potently induces IFN-α and IFN-regulated proteins from human PBMC.
PF 04878691 up-regulates the expression of CD83, CD86, and CD38 in IFN-beta-primed DC but not in immature DC.
PF 04878691 induces significantly less pDC maturation in cells from HIV+ individuals;

Physicochemical Properties

M.Wt 361.46
Formula C17H23N5O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[4-(4-Amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]methanesulfonamide

References

1. Severa M, et al. J Immunol. 2007 May 15;178(10):6208-16.

2. Gorden KK, et al. J Immunol. 2006 Dec 1;177(11):8164-70.

3. Martinson JA, et al. Cell Immunol. 2007 Nov-Dec;250(1-2):75-84.

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