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Chemical Structure : CU-CPT9b
CAS No.: 2162962-69-6
Catalog No.: PC-60332Not For Human Use, Lab Use Only.
CU-CPT9b (TLR8 inhibitor 9b) is a potent, selective TLR8 inhibitor with IC50 of 0.7 nM, Kd of 21 nM, and negligible cytotoxicity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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CU-CPT9b (TLR8 inhibitor 9b) is a potent, selective TLR8 inhibitor with IC50 of 0.7 nM, Kd of 21 nM, and negligible cytotoxicity.
CU-CPT9b shows no significant inhibition for other TLRs at 1 uM in cellular assays.
CU-CPT9b consistently recognizes an allosteric pocket on the protein-protein interface, stabilizing the inactive TLR8 dimer.
| M.Wt | 251.285 | |
| Formula | C16H13NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-(4-hydroxy-3-methylphenyl)quinolin-7-ol |
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1. Zhang S, et al. Nat Chem Biol. 2017 Nov 20. doi: 10.1038/nchembio.2518.
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