CU-CPT9b |CAS:2162962-69-6 Probechem Biochemicals

Chemical Structure : CU-CPT9b

CAS No.: 2162962-69-6

CU-CPT9b (TLR8 inhibitor 9b)

Catalog No.: PC-60332Not For Human Use, Lab Use Only.

CU-CPT9b (TLR8 inhibitor 9b) is a potent, selective TLR8 inhibitor with IC50 of 0.7 nM, Kd of 21 nM, and negligible cytotoxicity.

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$148	In stock
25 mg	$258	In stock
50 mg	$398	In stock
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Biological Activity

CU-CPT9b (TLR8 inhibitor 9b) is a potent, selective TLR8 inhibitor with IC50 of 0.7 nM, Kd of 21 nM, and negligible cytotoxicity.
CU-CPT9b shows no significant inhibition for other TLRs at 1 uM in cellular assays.
CU-CPT9b consistently recognizes an allosteric pocket on the protein-protein interface, stabilizing the inactive TLR8 dimer.

Physicochemical Properties

M.Wt	251.285
Formula	C16H13NO2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-hydroxy-3-methylphenyl)quinolin-7-ol

References

1. Zhang S, et al. Nat Chem Biol. 2017 Nov 20. doi: 10.1038/nchembio.2518.

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CU-CPT9b (TLR8 inhibitor 9b)

Biological Activity

Physicochemical Properties

References

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