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Chemical Structure : TLR9 inhibitor 18
Catalog No.: PC-61096Not For Human Use, Lab Use Only.
TLR9 inhibitor 18 is a potent, selective TLR9 antagonist with IC50 of 13 nM (human TLR9), displays 75-fold selectivity over TLR7 and no activity against TLR8 (IC50>10 uM).
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TLR9 inhibitor 18 is a potent, selective TLR9 antagonist with IC50 of 13 nM (human TLR9), displays 75-fold selectivity over TLR7 and no activity against TLR8 (IC50>10 uM).
TLR9 inhibitor 18 inhibits CpG-induced IL-6 production in mouse spleen and human PBMCs with IC50 of 74 and 244 nM, respectively.
TLR9 inhibitor 18 inhibits CpG-induced IL-6 production with ED50 of 0.8 mg/kg in mice, has great potential in the treatment of TLR9-mediated systemic uncontrollable inflammatory response like sepsis.
| M.Wt | 452.603 | |
| Formula | C25H36N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Watanabe M, et al. ACS Med Chem Lett. 2014 Oct 2;5(11):1235-9.
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