Catalog No.: PC-61096Not For Human Use, Lab Use Only.
TLR9 inhibitor 18 is a potent, selective TLR9 antagonist with IC50 of 13 nM (human TLR9), displays 75-fold selectivity over TLR7 and no activity against TLR8 (IC50>10 uM).
TLR9 inhibitor 18 is a potent, selective TLR9 antagonist with IC50 of 13 nM (human TLR9), displays 75-fold selectivity over TLR7 and no activity against TLR8 (IC50>10 uM).
TLR9 inhibitor 18 inhibits CpG-induced IL-6 production in mouse spleen and human PBMCs with IC50 of 74 and 244 nM, respectively.
TLR9 inhibitor 18 inhibits CpG-induced IL-6 production with ED50 of 0.8 mg/kg in mice, has great potential in the treatment of TLR9-mediated systemic uncontrollable inflammatory response like sepsis.
