| Cat. No. |
Product Name |
Information |
| PC-49127 |
E567
TLR2 inhibitor
|
E567 is a small molecule TLR2 signaling inhibitor with anti-viral activity, efficiently inhibits both LCMV and HSV-1 induced cytokine responses in both human and mouse cell cultures. |
| PC-49018 |
SMU-Z1
TLR1/2 agonist
|
SMU-Z1 is a potent, specific small molecule agonist of TLR1/2, specifically activates TLR2 through its association with TLR1, induces NF‐κB activation in HEK‐Blue hTLR2 cells with EC50 of 4.88 nM. |
| PC-47088 |
Diprovocim-X
TLR1/TLR2 agonist
|
Diprovocim-X is a potent human and murine TLR1/TLR2 agonist with EC50 of 0.14 nM (hTLR1/TLR2) and 0.75 nM (m TLR1/TLR2), respectively. |
| PC-38500 |
BMS-905
TLR7/TLR8 inhibitor
|
BMS-905 is a potent dual inhibitor of TLR7 and TLR8 with IC50 of 0.3 nM (TLR7, IL-6 inhibition in mouse blood), shows good selectivity against TLR9 and other TLR family members. |
| PC-38433 |
Zenuzolac
Immunosuppressant
|
Zenuzolac (GLS1027, VGX-1027) is a small molecule immunosuppressant and an orally available isoxazole compound, inhibits toll-like receptor 4 (TLR4) activity, has shown promise for the treatment of several neuroinflammatory disorders. |
| PC-73443 |
Ruzotolimod
TLR7 agonist
|
Ruzotolimod (RO7020531) is a potent, selective, oral TLR7 agonist in clinical development as part of a curative regimen against chronic hepatitis B. |
| PC-73105 |
CU-72
TLR7/8 inhibitor
|
CU-72 is a potent, selective TLR7/8 dual inhibitor with IC50 of 5.10 and 2.87 uM, respectively. |
| PC-73063 |
1V209
TLR7 agonist
|
1V209 is a synthetic small molecule TLR7 specific ligand and agonist. |
| PC-72474 |
BMS-986256
TLR7/8 inhibitor
|
BMS-986256 (Afimetoran, BMS986256) is an orally active, potent and selective inhibitor antagonist of TLR7/8. |
| PC-72053 |
CU-CPD107
TLR8 agonist
|
CU-CPD107 is a TLR8-specific small molecule with unique synergistic agonist activities in the presence of ssRNA, but inactive without the aid of ssRNA. |
| PC-72052 |
CU-115
TLR8 inhibitor
|
CU-115 is a novel potent, selective TLR8 antagonist (inhibitor) with IC50 of 1.4 uM, shows no significant inhibitory effect on TLR7 (IC50>50 uM). |
| PC-72051 |
BMS-615
TLR789 inhibitor
|
TLR789 inhibitor 7f (BMS-615) is a potent, orally bioavailable antagonist of Toll-like Receptor 7/8/9 (TLR7/8/9) with IC50 of 10/17/700 nM in NF-kB reporter assays, does not inhibit TLR3/4. |
