| Cat. No. |
Product Name |
Information |
| PC-36098 |
Selgantolimod
TLR8 agonist
|
Selgantolimod (GS-9688; GS9688) is a potent, selective and orally bioavailable TLR8 agonist with IL-12p40 EC50 of 220 nM, >100-fold TLR7 selectivity (IFN-α, EC50 >50 uM). |
| PC-35705 |
SMU127
TLR1/TLR2 agonist
|
SMU127 (SMU-127, ZINC666243) is a specific TLR1-TLR2 small molecule agonist with EC50 of 0.55 uM. |
| PC-35621 |
Diprovocim
TLR1/TLR2 agonist
|
Diprovocim is a potent Toll-like receptor TLR1/TLR2 agonist that induces dose-dependent TNF production with EC50 of 110 pM in human THP-1 cells and 1.3 nM in primary mouse peritoneal macrophages. |
| PC-63387 |
SM-324405
TLR7 agonist
|
SM-324405 is a potent, selective TLR7 agonist with EC50 of 50 nM, induces IFN-α and -γ expression in human PBMCs and mouse splenocytes, inhibits IL-5 production in human PBMCs in vitro. |
| PC-63386 |
AZ12441970
TLR7 agonist
|
AZ12441970 is a selective TLR7 agonist with pEC50 of 6.8 and 6.6 for human and rat TLR7, shows inactivity against TLR8. |
| PC-63385 |
GSK2245035
TLR7 agonist
|
GSK2245035 is a highly potent, selective TLR7 agonist that selectively induces TFN-α in PBMC assays with pEC50 of 9.3, >2 logs selectivity over TNFα pEC50. |
| PC-63373 |
T5342126 hydrochloride
TLR4 inhibitor
|
T5342126 hydrochloride is a potent, selective TLR4 inhibitor, inhibits LPS-induced NO production in RAW 264 macrophage cells with IC50 of 27.8 uM. |
| PC-63372 |
T5342126
TLR4 inhibitor
|
T5342126 is a potent, selective TLR4 inhibitor, inhibits LPS-induced NO production in RAW 264 macrophage cells with IC50 of 27.8 uM. |
| PC-63208 |
IAXO-102
TLR4 inhibitor
|
IAXO-102 is a novel selective TLR4 antagonist, negatively regulates non-hematopoietic TLR4 signalling and inhibits experimental AAA development. |
| PC-42816 |
TAK-242
TLR4 inhibitor
|
TAK-242 (Resatorvid) is a small molecule TLR4 signaling inhibitor that suppresses LPS-induced production of NO, TNF-alpha and IL-6 in RAW264.7 cells and mouse peritoneal macrophages with IC50 of 1.1-11 nM. |
| PC-62974 |
o-vanillin
TLR2 inhibitor
|
o-vanillin (C29L, ortho-Vanillin) is the C29 derivative that blocks hTLR2/1 and hTLR2/6 signaling with IC50 of 24.2 uM and 37.2 uM in NF-κB reporter assay in HEK293T cells, respectively. |
| PC-62780 |
ANA975
TLR7 agonist
|
ANA975 is an oral prodrug of the TLR-7 agonist Isatoribine (ANA245, 7-Thia-8-oxoguanosine) against hepatitis C virus (HCV) infection. |
