| Cat. No. |
Product Name |
Information |
| PC-25313 |
TLR7/8 antagonist 1
TLR7/8 antagonist
|
TLR7/8 antagonist 1 is a potent TLR7 and TLR8 antagonist with IC50 of 3.91 uM and 2.19 uM respectively, inhibits agonist induced TNFα, IFNγ, and IL-1β. |
| PC-25312 |
TLR 7/8 agonist 558
TLR7/8 agonist
|
TLR 7/8 agonist 558 (TLR7/8 agonist 6) is a potent TLR7 and TLR8 small molecule agonist with EC50 of 0.18 uM and 5.34 uM respectively, stimulates TNFα, IFNγ, and IL-1β. |
| PC-25126 |
SMU-CX1
TLR3 inhibitor
|
SMU-CX1 is a specific TLR3 inhibitor, inhibits TLR3-mediated SEAP signaling with IC50 of 0.11 uM, inhibits influenza A virus (IAV) and SARS-CoV-2 activity. |
| PC-24869 |
KBD4466
TLR7/8 inhibitor
|
KBD4466 is a potent, highly selective inhibitor of TLR7/8 with IC50 of 0.9/2.8 nM respectively in HEK293 cellular reporter assays, does not inhibit TLR9. |
| PC-24366 |
IMDQ
TLR7/8 agonist
|
IMDQ is a highly potent, specific TLR7/8 agonist with EC50 of 8.58 nM in human TLR7-specific reporter gene assay. |
| PC-22807 |
LHC165
TLR7 agonist
|
LHC165 is a potent, selective TLR7 agonist, generates effective tumor antigen-specific T-cell adaptive immune response as well as durable antitumor responses. |
| PC-22592 |
CL264
TLR7 agonist
|
CL264 is a potent, selective toll like receptor 7 (TLR7) agonist and resiquimod analogue. |
| PC-22583 |
PVP-037.1
TLR7/8 agonist
|
PVP-037.1 is a small-molecule that induces cytokine production and TLR7/8 agonist, demonstrates TLR7-dependent enhancement of TH1-polarizing adjuvanticity. |
| PC-22582 |
PVP-037
TLR7/8 agonist
|
PVP-037 is a small-molecule that induces cytokine production, demonstrates TLR7-dependent enhancement of TH1-polarizing adjuvanticity. |
| PC-22146 |
E6446 dihydrochloride
TLR7/TLR9 inhibitor
|
E6446 dihydrochloride is a potent, orally available small molecule inhibitor of TLR7 and TLR9 with IC50 of 1.78 uM and 0.01 uM, respectively. |
| PC-21750 |
TLR7 agonist 20
TLR7 agonist
|
TLR7 agonist 20 is a potent, selective TLR7 agonist with EC50 of 12 nM and 17 nM for hTLR and mTLR7 in cell-based reporter assay, respectively. |
| PC-21154 |
TLR7 agonist 17b
TLR7 agonist
|
TLR7 agonist 17b is a potent, selective TLR7 agonist with EC50 of 18 nM in Ramos Blue reporter assays, >500-fold selective for TLR7 over TLR8. |
