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Chemical Structure : E6446 dihydrochloride
CAS No.: 1345675-25-3
Catalog No.: PC-22146Not For Human Use, Lab Use Only.
E6446 dihydrochloride is a potent, orally available small molecule inhibitor of TLR7 and TLR9 with IC50 of 1.78 uM and 0.01 uM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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E6446 dihydrochloride is a potent, orally available small molecule inhibitor of TLR7 and TLR9 with IC50 of 1.78 uM and 0.01 uM, respectively.
E6446 shows weak activity against TLR4 (IC50=10.58 uM).
E6446 potently inhibits IL-6 production induced by CpG2216 and suppresses both IL-6 and α-interferon production induced by CpG oligo.
E6446 prevents DNA-TLR9 interaction in vitro and modulates signaling in vivo.
| M.Wt | 522.51 | |
| Formula | C27H37Cl2N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-(3-Pyrrolidin-1-yl-propoxy)-2-[4-(3-pyrrolidin-1-yl-propoxy)-phenyl]-benzooxazole dihydrochloride |
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1. Lamphier M, et al. Mol Pharmacol. 2014 Mar;85(3):429-40.
2. Franklin BS, et al. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3689-94.
3. Dias AA, et al. J Immunol. 2016 Sep 1;197(5):1905-13.
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