Chemical Structure : E6446 dihydrochloride
CAS No.:
1345675-25-3
E6446 dihydrochloride
(E-6446 dihydrochloride)
Catalog No. : PC-22146Not For Human Use, Lab Use Only.
E6446 dihydrochloride is a potent, orally available small molecule inhibitor of TLR7 and TLR9 with IC50 of 1.78 uM and 0.01 uM, respectively.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-2214601
Biological Activity
E6446 dihydrochloride is a potent, orally available small molecule inhibitor of TLR7 and TLR9 with IC50 of 1.78 uM and 0.01 uM, respectively.
Physicochemical Properties
M.Wt
522.51
Formula
C27H37Cl2N3O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
6-(3-Pyrrolidin-1-yl-propoxy)-2-[4-(3-pyrrolidin-1-yl-propoxy)-phenyl]-benzooxazole dihydrochloride
References
1. Lamphier M, et al. Mol Pharmacol. 2014 Mar;85(3):429-40.
2. Franklin BS, et al. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3689-94.
3. Dias AA, et al. J Immunol. 2016 Sep 1;197(5):1905-13.
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