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Chemical Structure : TLR7 agonist 17b
Catalog No.: PC-21154Not For Human Use, Lab Use Only.
TLR7 agonist 17b is a potent, selective TLR7 agonist with EC50 of 18 nM in Ramos Blue reporter assays, >500-fold selective for TLR7 over TLR8.
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TLR7 agonist 17b is a potent, selective TLR7 agonist with EC50 of 18 nM in Ramos Blue reporter assays, >500-fold selective for TLR7 over TLR8.
TLR7 agonist 17b 35-fold more potent than R848.
TLR7 agonist 17b potently induces the release of IFNα and TNFα from hPBMCs at low-nanomolar concentrations.
| M.Wt | 516.65 | |
| Formula | C29H36N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Emma G. DeYoung, et al. ACS Medicinal Chemistry Letters 2023
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