| Cat. No. |
Product Name |
Information |
| PC-42816 |
TAK-242
TLR4 inhibitor
|
TAK-242 (Resatorvid) is a small molecule TLR4 signaling inhibitor that suppresses LPS-induced production of NO, TNF-alpha and IL-6 in RAW264.7 cells and mouse peritoneal macrophages with IC50 of 1.1-11 nM. |
| PC-62974 |
o-vanillin
TLR2 inhibitor
|
o-vanillin (C29L, ortho-Vanillin) is the C29 derivative that blocks hTLR2/1 and hTLR2/6 signaling with IC50 of 24.2 uM and 37.2 uM in NF-κB reporter assay in HEK293T cells, respectively. |
| PC-62780 |
ANA975
TLR7 agonist
|
ANA975 is an oral prodrug of the TLR-7 agonist Isatoribine (ANA245, 7-Thia-8-oxoguanosine) against hepatitis C virus (HCV) infection. |
| PC-62779 |
Isatoribine
TLR7 agonist
|
Isatoribine (ANA245; 7-Thia-8-oxoguanosine; Immunosine) is a nucleoside analogue, selective agonist of TLR7 with significant antiviral effect and mmunoenhancing activity. |
| PC-62232 |
E6446
TLR7/TLR9 inhibitor
|
E 6446 is a novel orally available small molecule inhibitor of TLR7 and TLR9 with IC50 of 1.78 uM and 0.01 uM, respectively. |
| PC-62231 |
AT791
TLR7/TLR9 inhibitor
|
AT791 is a novel orally available, small molecule inhibitor of TLR7 and TLR9 with IC50 of 3.33 uM and 0.04 uM respectively, inhibits DNA-TLR9 interaction in vitro. |
| PC-61902 |
Semapimod
TLR4 inhibitor
|
Semapimod (CNI-1493, AXD-455) is a tetravalent guanylhydrazone that acts as a selective inhibitor of cytokine-inducible arginine transport and NO production, inhibits TLR4 signaling (IC50=0.3 uM) by targeting the TLR chaperone gp96. |
| PC-61901 |
Semapimod hydrochloride
TLR4 inhibitor
|
Semapimod (CNI-1493, AXD-455) is a tetravalent guanylhydrazone that acts as a selective inhibitor of cytokine-inducible arginine transport and NO production, inhibits TLR4 signaling (IC50=0.3 uM) by targeting the TLR chaperone gp96. |
| PC-61400 |
Telratolimod
TLR7/8 agonist
|
Telratolimod (MEDI 9197, 3M 052) is a novel, injectable, tissue-retained TLR7/8 agonist that forms a tissue depot with gradual, sustained release, allowing local TLR triggering activity without systemic cytokine release. |
| PC-70318 |
1Z105
TLR4 agonist
|
1Z105 is a novel synthetic, orally bioavailable TLR4/MD2 ligand, significantly reduces the IL-6 secretion by subsequent challenge with LPS at 0.63 uM. |
| PC-70307 |
TLR7 agonist 54
TLR7 agonist
|
TLR7 agonist 54 is a potent TLR7 agonist with EC50 of 8.6 nM. |
| PC-70306 |
TLR7 agonist 31
TLR7 agonist
|
TLR7 agonist 31 (BBIQ) is a potent TLR7 agonist with EC50 of 59 nM. |
