| Cat. No. |
Product Name |
Information |
| PC-70302 |
3M-002
TLR8 agonist
|
3M-002 (CL-075) is a selective TLR8 agonist that induces activation of NF-κB at 0.4 uM. |
| PC-61095 |
CPG-52364
TLR7/8/9 antagonist
|
CPG-52364 (CPG52364) is an orally available, small molecule TLR7/8/9 antagonist for the treatment of systemic lupus erythematosus and other autoimmune disorders.. |
| PC-60332 |
CU-CPT9b
TLR8 inhibitor
|
CU-CPT9b (TLR8 inhibitor 9b) is a potent, selective TLR8 inhibitor with IC50 of 0.7 nM, Kd of 21 nM, and negligible cytotoxicity. |
| PC-60331 |
CU-CPT9a
TLR8 inhibitor
|
CU-CPT9a (TLR8 inhibitor 9a) is a potent, selective TLR8 inhibitor with IC50 of 0.5 nM, and negligible cytotoxicity. |
| PC-60002 |
CU-CPT8m
TLR8 inhibitor
|
CU-CPT8m is a novel potent, selective TLR8 inhibitor with Kd of 220 nM and IC50 of 67 nM, with negligible cytotoxicity. |
| PC-42165 |
C29
TLR2 inhibitor
|
TLR2 inhibitor C-29 is a small molecule TLR2 inhibitor that blocks hTLR2/1 and hTLR2/6 signaling with IC50 of 19.7 uM and 37.6 uM, respectively, in NF-κB reporter assay in HEK293T cells. |
| PC-22146 |
E6446 dihydrochloride
TLR7/TLR9 inhibitor
|
E6446 dihydrochloride is a potent, orally available small molecule inhibitor of TLR7 and TLR9 with IC50 of 1.78 uM and 0.01 uM, respectively. |
| PC-22025 |
GY101
TLR7 agonist
|
GY101 is a potent, selective TLR7 agonist, activates the TLR7/NF-κB signaling pathway with EC50 of 0.15 uM. |
| PC-21750 |
TLR7 agonist 20
TLR7 agonist
|
TLR7 agonist 20 is a potent, selective TLR7 agonist with EC50 of 12 nM and 17 nM for hTLR and mTLR7 in cell-based reporter assay, respectively. |
| PC-21155 |
E104
TLR7 agonist
|
E014 is a potent, selective TLR7 agonist with EC50 of 69 nM in Ramos Blue reporter assays, >500-fold selective for TLR7 over TLR8. |
| PC-21154 |
TLR7 agonist 17b
TLR7 agonist
|
TLR7 agonist 17b is a potent, selective TLR7 agonist with EC50 of 18 nM in Ramos Blue reporter assays, >500-fold selective for TLR7 over TLR8. |
| PC-21103 |
Loxoribine
TLR7 agonist
|
Loxoribine (7-Allyl-8-oxoguanosine, RWJ21757) is a selective Toll-like receptor 7 (TLR7) agonist and immune modulator. |
