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AT791

Chemical Structure : AT791

CAS No.: 1219962-49-8

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AT791 (AT-791)

Catalog No.: PC-62231Not For Human Use, Lab Use Only.

AT791 is a novel orally available, small molecule inhibitor of TLR7 and TLR9 with IC50 of 3.33 uM and 0.04 uM respectively, inhibits DNA-TLR9 interaction in vitro.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AT791 is a novel orally available, small molecule inhibitor of TLR7 and TLR9 with IC50 of 3.33 uM and 0.04 uM respectively, inhibits DNA-TLR9 interaction in vitro.
AT791  shows weak activity against TLR4 (IC50>10 uM).
AT791  potently inhibits IL-6 production induced by CpG2216 and suppresses both IL-6 and α-interferon production induced by CpG oligo.

Physicochemical Properties

M.Wt 397.519
Formula C23H31N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-[4-(6-(3-(dimethylamino)propoxy)benzo[d]oxazol-2-yl)phenoxy]-N,N-dimethylpropan-1-amine

References

1. Lamphier M, et al. Mol Pharmacol. 2014 Mar;85(3):429-40.

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