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Chemical Structure : TAK-242
CAS No.: 243984-11-4
Catalog No.: PC-42816Not For Human Use, Lab Use Only.
TAK-242 (Resatorvid) is a small molecule TLR4 signaling inhibitor that suppresses LPS-induced production of NO, TNF-alpha and IL-6 in RAW264.7 cells and mouse peritoneal macrophages with IC50 of 1.1-11 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $108 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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TAK-242 (Resatorvid) is a small molecule TLR4 signaling inhibitor that suppresses LPS-induced production of NO, TNF-alpha and IL-6 in RAW264.7 cells and mouse peritoneal macrophages with IC50 of 1.1-11 nM.
TAK-242 also suppresses the production of these cytokines from LPS-stimulated human PBMCs with IC50 of 11-33 nM, suppresses the cytokine production induced by TLR-4 ligands, but not by ligands for TLR2, -3, and -9.
TAK-242 binds to Cys747 in the intracellular domain of TLR4, inhibits MyD88-independent pathway as well as MyD88-dependent pathway.
TAK-242 demonstrates potent therapeutic effects on mouse sepsis model.
| M.Wt | 361.8162 | |
| Formula | C15H17ClFNO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 360 mg/mL |
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| Chemical Name/SMILES |
1-Cyclohexene-1-carboxylic acid, 6-[[(2-chloro-4-fluorophenyl)amino]sulfonyl]-, ethyl ester, (6R)- |
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1. Yamada M, et al. J Med Chem. 2005 Nov 17;48(23):7457-67.
2. Ii M, et al. Mol Pharmacol. 2006 Apr;69(4):1288-95.
3. Sha T, et al. Eur J Pharmacol. 2007 Oct 1;571(2-3):231-9.
4. Takashima K, et al. Br J Pharmacol. 2009 Aug;157(7):1250-62.
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