| Cat. No. |
Product Name |
Information |
| PC-60332 |
CU-CPT9b
TLR8 inhibitor
|
CU-CPT9b (TLR8 inhibitor 9b) is a potent, selective TLR8 inhibitor with IC50 of 0.7 nM, Kd of 21 nM, and negligible cytotoxicity. |
| PC-60331 |
CU-CPT9a
TLR8 inhibitor
|
CU-CPT9a (TLR8 inhibitor 9a) is a potent, selective TLR8 inhibitor with IC50 of 0.5 nM, and negligible cytotoxicity. |
| PC-60002 |
CU-CPT-8m
TLR8 inhibitor
|
CU-CPT-8m is a novel potent, selective TLR8 inhibitor with Kd of 220 nM and IC50 of 67 nM, with negligible cytotoxicity. |
| PC-42165 |
TL2-C29
TLR2 inhibitor
|
TL2-C29 (TLR2 inhibitor C29) is a small molecule TLR2 inhibitor that blocks hTLR2/1 and hTLR2/6 signaling with IC50 of 19.7 uM and 37.6 uM, respectively, in NF-κB reporter assay in HEK293T cells. |
| PC-26697 |
AXC-715 trihydrochloride
TLR7 agonist
|
AXC-715 (T785) trihydrochloride is a small-molecule TLR7 agonist, elicits broad-spectrum antiviral effects, stabilizes TLR7 receptor dimerization to inhibit viral replication. |
| PC-26696 |
AXC-715 hydrochloride
TLR7 agonist
|
AXC-715 (T785) hydrochloride is a small-molecule TLR7 agonist, elicits broad-spectrum antiviral effects, stabilizes TLR7 receptor dimerization to inhibit viral replication. |
| PC-26695 |
AXC-715
TLR7 agonist
|
AXC-715 (T785) is a small-molecule TLR7 agonist, elicits broad-spectrum antiviral effects, stabilizes TLR7 receptor dimerization to inhibit viral replication. |
| PC-26660 |
L48H37
TLR4 inhibitor, MD2 inhibitor
|
L48H37 is a curcumin analog that specifically targets myeloid differentiation protein 2 (MD2) and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. |
| PC-26584 |
TLR4-IN-C34
TLR4 inhibitor
|
TLR4-IN-C34 is a potent TLR4 antagonist, inhibits LPS-induced IL6, IL1β, and TNFα mRNA levels in IEC6 cells, inhibits TLR4 in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. |
| PC-26537 |
TH1027
TLR8 inhibitor
|
TH1027 is a highly potent and specific inhibitor of TLR8, dose-dependently inhibited R848-or ssRNA06-induced TLR8 activation with IC50 of 30 nM. |
| PC-26536 |
TLR8 antagonist 35
TLR8 inhibitor
|
TLR8 antagonist 35 is a potent, selective TLR8 antagonist with IC50 of 32 nM in hTLR8-HEK293 reporter cells. |
| PC-26477 |
ENDO3
STX7-Munc13-4 inhibitor
|
ENDO3 is a specific small-molecule inhibitor of syntaxin 7 (STX7)-Munc13-4 interaction, selectively blocks endosomal TLRs (eTLRs) endosomal signaling, inhibits CD40 mobilization in Cal1 cells stimulated with CpG with IC50 of 0.12 uM, directly binds to recombinant STX7 with SPR KD of 3.13 uM. |
