| Cat. No. |
Product Name |
Information |
| PC-20180 |
TLR3-dsRNA complex inhibitor
TLR3 inhibitor
|
TLR3/dsRNA Complex Inhibitor (CU-CPT4a, TLR3i) is a specific small molecule inhibitor targeting the dsRNA binding region of TLR3 with Ki of 2.96 uM, blocks Poly (I:C)-induced TLR3 activation with IC50 of 3.44 uM. |
| PC-73460 |
Polvitolimod
TLR7 agonist
|
Polvitolimod is a toll-like receptor 7 (TLR7) agonist for treatment of cancer and infectious disease. |
| PC-73443 |
Ruzotolimod
TLR7 agonist
|
Ruzotolimod (RO7020531) is a potent, selective, oral TLR7 agonist in clinical development as part of a curative regimen against chronic hepatitis B. |
| PC-73105 |
CU-72
TLR7/8 inhibitor
|
CU-72 is a potent, selective TLR7/8 dual inhibitor with IC50 of 5.10 and 2.87 uM, respectively. |
| PC-72474 |
BMS-986256
TLR7/8 inhibitor
|
BMS-986256 (Afimetoran, BMS986256) is an orally active, potent and selective inhibitor antagonist of TLR7/8. |
| PC-72053 |
CU-CPD107
TLR8 modulator
|
CU-CPD107 is a TLR8-specific small molecule with unique synergistic agonist activities in the presence of ssRNA, but inactive without the aid of ssRNA. |
| PC-72051 |
TLR789 inhibitor 7f
TLR789 inhibitor
|
TLR789 inhibitor 7f is a potent, orally bioavailable antagonist of Toll-like Receptor 7/8/9 (TLR7/8/9) with IC50 of 10/17/700 nM in NF-kB reporter assays, does not inhibit TLR3/4. |
| PC-35315 |
TLR7 and 8 modulator 31
|
TLR7 and 8 modulator 31 is a potent, orally active, dual TLR7 and 8 agonist with LEC values of 0.15 and 0.16 uM, respectively. |
