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Request The Product List ofToll-like Receptor (TLR) Toll-like Receptor (TLR)

Cat. No. Product Name Information
PC-60002

CU-CPT8m

TLR8 inhibitor

CU-CPT8m is a novel potent, selective TLR8 inhibitor with Kd of 220 nM and IC50 of 67 nM, with negligible cytotoxicity.
PC-42165

TL2-C29

TLR2 inhibitor

TL2-C29 (TLR2 inhibitor C29) is a small molecule TLR2 inhibitor that blocks hTLR2/1 and hTLR2/6 signaling with IC50 of 19.7 uM and 37.6 uM, respectively, in NF-κB reporter assay in HEK293T cells.
PC-25546

TLR9 antagonist 38

TLR9 antagonist

TLR9 antagonist 38 is a highly potent, selective TLR9 antagonist with IC50 of 0.1 nM (hTLR9), >10,000-fold selectivity over hTLR2/4/5/7/8.
PC-25491

ETI60

TLR inhibitor

ETI60 (endosomal TLR inhibitor 60) is a potent, selective inhibitor of endosomal Toll-like receptors (TLR3, TLR7, TLR8 and TLR9) with IC50 of 20-3 00 nM for TLR3, TLR7 and TLR9, and 2 uM for TLR8.
PC-25490

ETI41

TLR inhibitor

ETI41 (endosomal TLR inhibitor 41) is a potent, selective inhibitor of endosomal Toll-like receptors (TLR3, TLR7, TLR8 and TLR9) with IC50 of 100-1000 nM.
PC-25432

CL097

TLR7/8 agonist

CL097 is a specific small molecule TLR-7/TLR-8 agonist, inhibits TLR-4--dependent activation of IRAK-M and BCL-3 expression, induces human pDC activation.
PC-25430

SMU-L11

TLR7 agonist

SMU-L11 is a potent, selecitve small-molecule TLR7 agonist with EC50 of 24 nM (hTLR7).
PC-25313

TLR7/8 antagonist 1

TLR7/8 antagonist

TLR7/8 antagonist 1 is a potent TLR7 and TLR8 antagonist with IC50 of 3.91 uM and 2.19 uM respectively, inhibits agonist induced TNFα, IFNγ, and IL-1β.
PC-25312

TLR 7/8 agonist 558

TLR7/8 agonist

TLR 7/8 agonist 558 (TLR7/8 agonist 6) is a potent TLR7 and TLR8 small molecule agonist with EC50 of 0.18 uM and 5.34 uM respectively, stimulates TNFα, IFNγ, and IL-1β.
PC-25128

SMU-C80

TLR1/2 agonist

SMU-C80 is a highly efficient and specific human TLR1/2 agonist, effectively promotes the SEAP signals in HEK-Blue hTLR2 cells with EC50 of 31.02 nM.
PC-25127

CU-T12-9

TLR1/2 agonist

CU-T12-9 is a specific TLR1/2 agonist with EC50 of 52.9 nM, directly targets TLR1/2 to initiate downstream signaling, induces TLR1/2 heterodimerization.
PC-25126

SMU-CX1

TLR3 inhibitor

SMU-CX1 is a specific TLR3 inhibitor, inhibits TLR3-mediated SEAP signaling with IC50 of 0.11 uM, inhibits influenza A virus (IAV) and SARS-CoV-2 activity.

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