| Cat. No. |
Product Name |
Information |
| PC-70303 |
PF-4878691
TLR7 agonist
|
PF-4878691 (PF-04878691, S32865, 3M-852A) is a selective TLR7 agonist that potently induces IFN-α and IFN-regulated proteins from human PBMC. |
| PC-70302 |
CL075
TLR8 agonist
|
CL075 (3M002) is a selective TLR8 agonist that induces activation of NF-κB at 0.4 uM. |
| PC-61096 |
TLR9 inhibitor 18
TLR9 inhibitor
|
TLR9 inhibitor 18 is a potent, selective TLR9 antagonist with IC50 of 13 nM (human TLR9), displays 75-fold selectivity over TLR7 and no activity against TLR8 (IC50>10 uM). |
| PC-61095 |
CPG-52364
TLR7/8/9 antagonist
|
CPG-52364 (CPG52364) is an orally available, small molecule TLR7/8/9 antagonist for the treatment of systemic lupus erythematosus and other autoimmune disorders.. |
| PC-60332 |
CU-CPT9b
TLR8 inhibitor
|
CU-CPT9b (TLR8 inhibitor 9b) is a potent, selective TLR8 inhibitor with IC50 of 0.7 nM, Kd of 21 nM, and negligible cytotoxicity. |
| PC-60331 |
CU-CPT9a
TLR8 inhibitor
|
CU-CPT9a (TLR8 inhibitor 9a) is a potent, selective TLR8 inhibitor with IC50 of 0.5 nM, and negligible cytotoxicity. |
| PC-60002 |
CU-CPT-8m
TLR8 inhibitor
|
CU-CPT-8m is a novel potent, selective TLR8 inhibitor with Kd of 220 nM and IC50 of 67 nM, with negligible cytotoxicity. |
| PC-42165 |
TL2-C29
TLR2 inhibitor
|
TL2-C29 (TLR2 inhibitor C29) is a small molecule TLR2 inhibitor that blocks hTLR2/1 and hTLR2/6 signaling with IC50 of 19.7 uM and 37.6 uM, respectively, in NF-κB reporter assay in HEK293T cells. |
| PC-27774 |
TLR7/8/9 triple antagonist 41
TLR7/8/9 antagonist
|
TLR7/8/9 triple antagonist 41 is a potent, selective triple antagonist of TLR7/8/9 with IC50 of 8/6/72 nM for hTLR7/8/9 respectively. |
| PC-27719 |
INI-4001
TLR7/8 agonist
|
INI-4001 is a selective, synthetic TLR7/8 agonist with EC50 of 1.89/4.86 uM, regulates innate and adaptive immune responses, acts as a vaccine adjuvant. |
| PC-27362 |
TLR4 agonist RS09
TLR4 agonist
|
TLR4 agonist RS09 (RS-09) is a peptide mimic TLR4 agonist, mimics the interaction between TLR-4 and LPS, binds TLR-4 and induces nuclear localization of NF-κB in the macrophage cell line RAW264.7, functions as an adjuvant in vivo. |
| PC-26844 |
Agatolimod
TLR9 agonist
|
Agatolimod ((ODN2006, PF-3512676; CpG 7909)) is an immunomodulating synthetic oligonucleotide designed to specifically agonise the Toll-like receptor 9 (TLR9) with EC50 of 180 nM against human TLR9. |
