| Cat. No. |
Product Name |
Information |
| PC-26660 |
L48H37
TLR4 inhibitor, MD2 inhibitor
|
L48H37 is a curcumin analog that specifically targets myeloid differentiation protein 2 (MD2) and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. |
| PC-26584 |
TLR4-IN-C34
TLR4 inhibitor
|
TLR4-IN-C34 is a potent TLR4 antagonist, inhibits LPS-induced IL6, IL1β, and TNFα mRNA levels in IEC6 cells, inhibits TLR4 in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. |
| PC-26537 |
TH1027
TLR8 inhibitor
|
TH1027 is a highly potent and specific inhibitor of TLR8, dose-dependently inhibited R848-or ssRNA06-induced TLR8 activation with IC50 of 30 nM. |
| PC-26536 |
TLR8 antagonist 35
TLR8 inhibitor
|
TLR8 antagonist 35 is a potent, selective TLR8 antagonist with IC50 of 32 nM in hTLR8-HEK293 reporter cells. |
| PC-25491 |
ETI60
TLR inhibitor
|
ETI60 (endosomal TLR inhibitor 60) is a potent, selective inhibitor of endosomal Toll-like receptors (TLR3, TLR7, TLR8 and TLR9) with IC50 of 20-3 00 nM for TLR3, TLR7 and TLR9, and 2 uM for TLR8. |
| PC-25490 |
ETI41
TLR inhibitor
|
ETI41 (endosomal TLR inhibitor 41) is a potent, selective inhibitor of endosomal Toll-like receptors (TLR3, TLR7, TLR8 and TLR9) with IC50 of 100-1000 nM. |
| PC-25432 |
CL097
TLR7/8 agonist
|
CL097 is a specific small molecule TLR-7/TLR-8 agonist, inhibits TLR-4--dependent activation of IRAK-M and BCL-3 expression, induces human pDC activation. |
| PC-25430 |
SMU-L11
TLR7 agonist
|
SMU-L11 is a potent, selecitve small-molecule TLR7 agonist with EC50 of 24 nM (hTLR7). |
| PC-25313 |
TLR7/8 antagonist 1
TLR7/8 antagonist
|
TLR7/8 antagonist 1 is a potent TLR7 and TLR8 antagonist with IC50 of 3.91 uM and 2.19 uM respectively, inhibits agonist induced TNFα, IFNγ, and IL-1β. |
| PC-25312 |
TLR 7/8 agonist 558
TLR7/8 agonist
|
TLR 7/8 agonist 558 (TLR7/8 agonist 6) is a potent TLR7 and TLR8 small molecule agonist with EC50 of 0.18 uM and 5.34 uM respectively, stimulates TNFα, IFNγ, and IL-1β. |
| PC-25126 |
SMU-CX1
TLR3 inhibitor
|
SMU-CX1 is a specific TLR3 inhibitor, inhibits TLR3-mediated SEAP signaling with IC50 of 0.11 uM, inhibits influenza A virus (IAV) and SARS-CoV-2 activity. |
| PC-24869 |
KBD4466
TLR7/8 inhibitor
|
KBD4466 is a potent, highly selective inhibitor of TLR7/8 with IC50 of 0.9/2.8 nM respectively in HEK293 cellular reporter assays, does not inhibit TLR9. |
