| Cat. No. |
Product Name |
Information |
| PC-27774 |
TLR7/8/9 triple antagonist 41
TLR7/8/9 antagonist
|
TLR7/8/9 triple antagonist 41 is a potent, selective triple antagonist of TLR7/8/9 with IC50 of 8/6/72 nM for hTLR7/8/9 respectively. |
| PC-27719 |
INI-4001
TLR7/8 agonist
|
INI-4001 is a selective, synthetic TLR7/8 agonist with EC50 of 1.89/4.86 uM, regulates innate and adaptive immune responses, acts as a vaccine adjuvant. |
| PC-27362 |
TLR4 agonist RS09
TLR4 agonist
|
TLR4 agonist RS09 (RS-09) is a peptide mimic TLR4 agonist, mimics the interaction between TLR-4 and LPS, binds TLR-4 and induces nuclear localization of NF-κB in the macrophage cell line RAW264.7, functions as an adjuvant in vivo. |
| PC-26844 |
Agatolimod
TLR9 agonist
|
Agatolimod ((ODN2006, PF-3512676; CpG 7909)) is an immunomodulating synthetic oligonucleotide designed to specifically agonise the Toll-like receptor 9 (TLR9) with EC50 of 180 nM against human TLR9. |
| PC-26697 |
AXC-715 trihydrochloride
TLR7 agonist
|
AXC-715 (T785) trihydrochloride is a small-molecule TLR7 agonist, elicits broad-spectrum antiviral effects, stabilizes TLR7 receptor dimerization to inhibit viral replication. |
| PC-26584 |
TLR4-IN-C34
TLR4 inhibitor
|
TLR4-IN-C34 is a potent TLR4 antagonist, inhibits LPS-induced IL6, IL1β, and TNFα mRNA levels in IEC6 cells, inhibits TLR4 in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. |
| PC-26537 |
TH1027
TLR8 inhibitor
|
TH1027 is a highly potent and specific inhibitor of TLR8, dose-dependently inhibited R848-or ssRNA06-induced TLR8 activation with IC50 of 30 nM. |
| PC-26536 |
TLR8 antagonist 35
TLR8 inhibitor
|
TLR8 antagonist 35 is a potent, selective TLR8 antagonist with IC50 of 32 nM in hTLR8-HEK293 reporter cells. |
| PC-25491 |
ETI60
TLR inhibitor
|
ETI60 (endosomal TLR inhibitor 60) is a potent, selective inhibitor of endosomal Toll-like receptors (TLR3, TLR7, TLR8 and TLR9) with IC50 of 20-3 00 nM for TLR3, TLR7 and TLR9, and 2 uM for TLR8. |
| PC-25490 |
ETI41
TLR inhibitor
|
ETI41 (endosomal TLR inhibitor 41) is a potent, selective inhibitor of endosomal Toll-like receptors (TLR3, TLR7, TLR8 and TLR9) with IC50 of 100-1000 nM. |
| PC-25432 |
CL097
TLR7/8 agonist
|
CL097 is a specific small molecule TLR-7/TLR-8 agonist, inhibits TLR-4--dependent activation of IRAK-M and BCL-3 expression, induces human pDC activation. |
| PC-25430 |
SMU-L11
TLR7 agonist
|
SMU-L11 is a potent, selecitve small-molecule TLR7 agonist with EC50 of 24 nM (hTLR7). |
