TLR7/8/9 triple antagonist 41

Chemical Structure : TLR7/8/9 triple antagonist 41

Catalog No.: PC-27774Not For Human Use, Lab Use Only.

TLR7/8/9 triple antagonist 41 is a potent, selective triple antagonist of TLR7/8/9 with IC50 of 8/6/72 nM for hTLR7/8/9 respectively.

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Biological Activity

TLR7/8/9 triple antagonist 41 is a potent, selective triple antagonist of TLR7/8/9 with IC50 of 8/6/72 nM for hTLR7/8/9 respectively.
TLR7/8/9 triple antagonist 41 demonstrated robust dose-dependent inhibition of TLR7 and TLR9 pathways in mouse challenging models.

Physicochemical Properties

M.Wt	483.62
Formula	C28H33N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((2R,6S)-2-methyl-6-((4-(5,6,7,8-tetrahydro-2,6-naphthyridin-3-yl)piperazin-1-yl)methyl)morpholino)quinoline-8-carbonitrile

References

1. Zhang Z, et al. J Med Chem. 2026 Aug 13;69(15):18665-18691.

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