TLR8 antagonist 35

You are here:Home-Chemical Inhibitors & Agonists-Immunology/Inflammation-Toll-like Receptor (TLR)-TLR8 antagonist 35

Chemical Structure : TLR8 antagonist 35

Catalog No.: PC-26536Not For Human Use, Lab Use Only.

TLR8 antagonist 35 is a potent, selective TLR8 antagonist with IC50 of 32 nM in hTLR8-HEK293 reporter cells.

Packing	Price	Stock	Quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TLR8 antagonist 35 is a potent, selective TLR8 antagonist with IC50 of 32 nM in hTLR8-HEK293 reporter cells.
TLR8 antagonist 35 shows 290- and 67-fold selectivity over hTLR7-and hTLR9-overexpressing cells.
TLR8 antagonist 35 demonstrates concentration-dependent inhibition of TNF secretion with IC50 of 14 nM in THP-1 macrophages and 107 nM in PBMCs, completely inhibits TL8-506-induced IL-8 secretion at 1 uM.
TLR8 antagonist 35 induces concentration-dependent reduction in cellular responses TLR8-stimulated THP-1 macrophages with IC50 of 2.2 nM.

Physicochemical Properties

M.Wt	418.54
Formula	C25H30N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-Isopropylpiperidin-4-yl)-4-(((2-methylquinazolin-4-yl)oxy)methyl)benzamide

References

1. Matziol T, et al. Eur J Med Chem. 2026 Apr 4;311:118822.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com