| Cat. No. |
Product Name |
Information |
| PC-26696 |
AXC-715 hydrochloride
TLR7 agonist
|
AXC-715 (T785) hydrochloride is a small-molecule TLR7 agonist, elicits broad-spectrum antiviral effects, stabilizes TLR7 receptor dimerization to inhibit viral replication. |
| PC-26695 |
AXC-715
TLR7 agonist
|
AXC-715 (T785) is a small-molecule TLR7 agonist, elicits broad-spectrum antiviral effects, stabilizes TLR7 receptor dimerization to inhibit viral replication. |
| PC-26478 |
ENDO12
STX7-Munc13-4 inhibitor, eTLR inhibitor
|
ENDO12 is a specific small-molecule inhibitor of syntaxin 7 (STX7)-Munc13-4 interaction, selectively blocks endosomal TLRs (eTLRs) endosomal signaling, inhibits CD40 mobilization in Cal1 cells stimulated with CpG, directly binds to recombinant STX7 with SPR KD of 2.7 uM. |
| PC-26179 |
PVP-057
TLR3 agonist
|
PVP-057 is a specific small molecule Toll-like receptor 3 (TLR3) agonist, activates TLR3-dependent IRF and NF-kB signaling. |
| PC-25826 |
NSF-951
TLR4 agonist
|
NSF-951 is a small molecule TLR4 agonist with binding KD of 16.01 uM, induces the pro-inflammatory cytokines via MyD88/TRIF signalling. |
| PC-24612 |
BNT411
TLR7 agonist
|
BNT411 is a potent, selective TLR7 agonist, induces IFNα release both in vitro and in vivo. |
| PC-23645 |
TH-407b
TLR7 inhibitor
|
TH-407b is a potent and selective TLR7 inhibitor, dose-dependently inhibits R848-induced TLR7 activation with IC50 of 0.23 uM in HEK-Blue hTLR7 cells. |
| PC-22584 |
PVP-037.2
TLR7/8 agonist
|
PVP-037.2 is a small-molecule that induces cytokine production, demonstrates TLR7-dependent enhancement of TH1-polarizing adjuvanticity. |
| PC-22025 |
GY101
TLR7 agonist
|
GY101 is a potent, selective TLR7 agonist, activates the TLR7/NF-κB signaling pathway with EC50 of 0.15 uM. |
| PC-21818 |
DSP-0509
TLR7 agonist
|
DSP-0509 (DSP0509) is a potent selective small-molecule TLR7 agonist with EC50 of 515 nM and 33 nM in cells expressing human and murine TLR7, respectively. |
| PC-21372 |
TH1020
TLR5 antagonist
|
TH1020 is a potent, selective antagonist of TLR5/flagellin protein-protein interaction with IC50 of 0.85 uM. |
| PC-21155 |
E104
TLR7 agonist
|
E014 is a potent, selective TLR7 agonist with EC50 of 69 nM in Ramos Blue reporter assays, >500-fold selective for TLR7 over TLR8. |
