| Cat. No. |
Product Name |
Information |
| PC-25125 |
SMU-C68
TLR1/2 agonist
|
SMU-C68 is a potent, selective human TLR1/2 agonist with EC50 of 9 nM in HEK-Blue hTLR2 cells, selectively targets the TLR1/2 heterodimer. |
| PC-24869 |
KBD4466
TLR7/8 inhibitor
|
KBD4466 is a potent, highly selective inhibitor of TLR7/8 with IC50 of 0.9/2.8 nM respectively in HEK293 cellular reporter assays, does not inhibit TLR9. |
| PC-24366 |
IMDQ
TLR7/8 agonist
|
IMDQ is a highly potent, specific TLR7/8 agonist with EC50 of 8.58 nM in human TLR7-specific reporter gene assay. |
| PC-24069 |
Oxymatrine
TLR2 agonist
|
Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway, also is a TLR2 agonist that directly bind to toll-like receptor 2 (TLR2). |
| PC-22807 |
LHC165
TLR7 agonist
|
LHC165 is a potent, selective TLR7 agonist, generates effective tumor antigen-specific T-cell adaptive immune response as well as durable antitumor responses. |
| PC-22703 |
TLR2 activator R-7d
TLR2 agonist
|
TLR2 activator R-7d is a highly potent and selective human TLR2 activator with EC50 of 116 pM in human THP-1 cells, promotes TLR1/2-induced NF-κB promoter activation. |
| PC-22592 |
CL264
TLR7 agonist
|
CL264 is a potent, selective toll like receptor 7 (TLR7) agonist and resiquimod analogue. |
| PC-22583 |
PVP-037.1
TLR7/8 agonist
|
PVP-037.1 is a small-molecule that induces cytokine production and TLR7/8 agonist, demonstrates TLR7-dependent enhancement of TH1-polarizing adjuvanticity. |
| PC-22582 |
PVP-037
TLR7/8 agonist
|
PVP-037 is a small-molecule that induces cytokine production, demonstrates TLR7-dependent enhancement of TH1-polarizing adjuvanticity. |
| PC-22146 |
E6446 dihydrochloride
TLR7/TLR9 inhibitor
|
E6446 dihydrochloride is a potent, orally available small molecule inhibitor of TLR7 and TLR9 with IC50 of 1.78 uM and 0.01 uM, respectively. |
| PC-21750 |
TLR7 agonist 20
TLR7 agonist
|
TLR7 agonist 20 is a potent, selective TLR7 agonist with EC50 of 12 nM and 17 nM for hTLR and mTLR7 in cell-based reporter assay, respectively. |
| PC-21154 |
TLR7 agonist 17b
TLR7 agonist
|
TLR7 agonist 17b is a potent, selective TLR7 agonist with EC50 of 18 nM in Ramos Blue reporter assays, >500-fold selective for TLR7 over TLR8. |
