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Xanthohumol

Chemical Structure : Xanthohumol

CAS No.: 6754-58-1

Xanthohumol

Catalog No.: PC-28587Not For Human Use, Lab Use Only.

Xanthohumol is a flavonoid isolated from hops, inhibits diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, shows anti-cancer and anti-angiogenic activities, inhibits LPS-induced TLR4 pathway by antagonizing the binding sites between LPS and Myeloid differentiation 2 (MD2), also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

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Biological Activity

Xanthohumol is a flavonoid isolated from hops, inhibits diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, shows anti-cancer and anti-angiogenic activities, inhibits LPS-induced TLR4 pathway by antagonizing the binding sites between LPS and Myeloid differentiation 2 (MD2), also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

Physicochemical Properties

M.Wt 354.40
Formula C21H22O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-1-(2,4-Dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one

References

1. Gallo C, et al. Oncotarget. 2016 Aug 1.

2. Yali Zhang, et al. Sci Rep. 2016 Apr 27:6:25130.

3. Arnaiz-Cot JJ, et al. J Pharmacol Exp Ther. 2016 Nov 4. pii: jpet.116.236588.

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