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Chemical Structure : CU-CPT9a
CAS No.: 2165340-32-7
Catalog No.: PC-60331Not For Human Use, Lab Use Only.
CU-CPT9a (TLR8 inhibitor 9a) is a potent, selective TLR8 inhibitor with IC50 of 0.5 nM, and negligible cytotoxicity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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CU-CPT9a (TLR8 inhibitor 9a) is a potent, selective TLR8 inhibitor with IC50 of 0.5 nM, and negligible cytotoxicity.
CU-CPT9a shows no significant inhibition for other TLRs at 1 uM in cellular assays.
CU-CPT9a consistently recognizes an allosteric pocket on the protein-protein interface, stabilizing the inactive TLR8 dimer.
CU-CPT9a shows significant inhibitory effects in suppressing the spontaneous release of TNF-α and IL-1β from synovial membrane cultures with little cytotoxicity up to 100 uM, also reduces the cytokine elevation in PMBCs derived from four patients with RA.
| M.Wt | 265.312 | |
| Formula | C17H15NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-(7-methoxyquinolin-4-yl)-2-methylphenol |
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1. Zhang S, et al. Nat Chem Biol. 2017 Nov 20. doi: 10.1038/nchembio.2518.
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