| Cat. No. |
Product Name |
Information |
| PC-20228 |
TL8-506
TLR8 agonist
|
TL8-506 is a potent, selective TLR8 agonist with EC50 of 30 nM for inducing NF-κB activation in TLR8-transfeceted HEK293 cells. |
| PC-20227 |
Motolimod
TLR8 agonist
|
Motolimod (VTX-2337) is a potent, selective small-molecule TLR8 agonist, stimulates PBMCs to produce TNFα and IL-12 with EC50 of 140 and 120 nM, respectively. |
| PC-20226 |
DSR-6434
TLR7 agonist
|
DSR-6434 (DSR6434) is a highly potent, specific TLR7 agonist with EC50 of 7.2 nM (hTLR7) and 4.6 nM (mTLR7) for stimulating reporter gene activity in HEK293 cells expressing TLR7. |
| PC-20180 |
CU-CPT4a
TLR3 inhibitor
|
TLR3/dsRNA Complex Inhibitor (CU-CPT4a, TLR3i) is a specific small molecule inhibitor targeting the dsRNA binding region of TLR3 with Ki of 2.96 uM, blocks Poly (I:C)-induced TLR3 activation with IC50 of 3.44 uM. |
| PC-49254 |
GS-9620
TLR7 agonist
|
Vesatolimod (GS-9620) is a potent and selective orally active small molecule agonist of Toll-like receptor 7 (TLR7) with EC50 of 291 nM. |
| PC-49146 |
SZU-106
TLR7 agonist
|
SZU-106 is a small molecule TLR7 agonist, selectively activates TLR7 and increases the expression of SEAP by activating the NF-κB pathway. |
| PC-49145 |
SZU-101
TLR7 agonist
|
SZU101 is a small molecule TLR7 agonist that directly activates, induces reporter activity (23-fold) in a TLR7-NF-kB reporter system expressed in HEK-293 cells TLR7 signalling. |
| PC-49127 |
E567
TLR2 inhibitor
|
E567 is a small molecule TLR2 signaling inhibitor with anti-viral activity, efficiently inhibits both LCMV and HSV-1 induced cytokine responses in both human and mouse cell cultures. |
| PC-49018 |
SMU-Z1
TLR1/2 agonist
|
SMU-Z1 is a potent, specific small molecule agonist of TLR1/2, specifically activates TLR2 through its association with TLR1, induces NF‐κB activation in HEK‐Blue hTLR2 cells with EC50 of 4.88 nM. |
| PC-47088 |
Diprovocim-X
TLR1/TLR2 agonist
|
Diprovocim-X is a potent human and murine TLR1/TLR2 agonist with EC50 of 0.14 nM (hTLR1/TLR2) and 0.75 nM (m TLR1/TLR2), respectively. |
| PC-38500 |
BMS-905
TLR7/TLR8 inhibitor
|
BMS-905 is a potent dual inhibitor of TLR7 and TLR8 with IC50 of 0.3 nM (TLR7, IL-6 inhibition in mouse blood), shows good selectivity against TLR9 and other TLR family members. |
| PC-38433 |
Zenuzolac
Immunosuppressant
|
Zenuzolac (GLS1027, VGX-1027) is a small molecule immunosuppressant and an orally available isoxazole compound, inhibits toll-like receptor 4 (TLR4) activity, has shown promise for the treatment of several neuroinflammatory disorders. |
