| Cat. No. |
Product Name |
Information |
| PC-25125 |
SMU-C68
TLR1/2 agonist
|
SMU-C68 is a potent, selective human TLR1/2 agonist with EC50 of 9 nM in HEK-Blue hTLR2 cells, selectively targets the TLR1/2 heterodimer. |
| PC-24612 |
BNT411
TLR7 agonist
|
BNT411 is a potent, selective TLR7 agonist, induces IFNα release both in vitro and in vivo. |
| PC-24069 |
Oxymatrine
TLR2 agonist
|
Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway, also is a TLR2 agonist that directly bind to toll-like receptor 2 (TLR2). |
| PC-23645 |
TH-407b
TLR7 inhibitor
|
TH-407b is a potent and selective TLR7 inhibitor, dose-dependently inhibits R848-induced TLR7 activation with IC50 of 0.23 uM in HEK-Blue hTLR7 cells. |
| PC-22703 |
TLR2 activator R-7d
TLR2 agonist
|
TLR2 activator R-7d is a highly potent and selective human TLR2 activator with EC50 of 116 pM in human THP-1 cells, promotes TLR1/2-induced NF-κB promoter activation. |
| PC-22584 |
PVP-037.2
TLR7/8 agonist
|
PVP-037.2 is a small-molecule that induces cytokine production, demonstrates TLR7-dependent enhancement of TH1-polarizing adjuvanticity. |
| PC-22025 |
GY101
TLR7 agonist
|
GY101 is a potent, selective TLR7 agonist, activates the TLR7/NF-κB signaling pathway with EC50 of 0.15 uM. |
| PC-21818 |
DSP-0509
TLR7 agonist
|
DSP-0509 (DSP0509) is a potent selective small-molecule TLR7 agonist with EC50 of 515 nM and 33 nM in cells expressing human and murine TLR7, respectively. |
| PC-21372 |
TH1020
TLR5 antagonist
|
TH1020 is a potent, selective antagonist of TLR5/flagellin protein-protein interaction with IC50 of 0.85 uM. |
| PC-21155 |
E104
TLR7 agonist
|
E014 is a potent, selective TLR7 agonist with EC50 of 69 nM in Ramos Blue reporter assays, >500-fold selective for TLR7 over TLR8. |
| PC-21010 |
E6742
TLR7/TLR8 inhibitor
|
E6742 (E-6742) is a potent, selective, dual TLR7/8 inhibitor with binding Kd of 1.7 uM/37 nM in ITC assays, respectively, inhibits TLR7/8 agonist CL097 induced reporter activation with IC50 values of 22, 68, and 3.0 nM for hTLR7, mTLR7, and hTLR8, respectively. |
| PC-20815 |
MHV370
TLR7/8 inhibitor
|
MHV370 (MHV-370) is a potent, selective, orally bioavailable inhibitor of Toll-like receptors 7 and 8 (TLR7/8) with IC50 of 1.1 and 4.5 nM in cell-based assays. |
