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Chemical Structure : SZU-101
Catalog No.: PC-49145Not For Human Use, Lab Use Only.
SZU101 is a small molecule TLR7 agonist that directly activates, induces reporter activity (23-fold) in a TLR7-NF-kB reporter system expressed in HEK-293 cells TLR7 signalling.
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SZU101 is a small molecule TLR7 agonist that directly activates, induces reporter activity (23-fold) in a TLR7-NF-kB reporter system expressed in HEK-293 cells TLR7 signalling.
SZU-101 activated dendritic cells, B cells and T cells and induced cytokine production but did not directly affect tumour cells.
SZU-101 in combination with doxorubicin improves survival and induces durable tumouricidal effects in a murine model of T cell lymphoma.
Intratumoral administration of SZU101 can change the tumor microenvironment and delay distant tumor growth.
SZU101 significantly suppressed PRRSV infection in primary porcine alveolar macrophages (PAMs) in a dose-dependent manner.
SZU101 enhanced the humoral and cell-mediated immune responses against PRRSV antigens in mice.
| M.Wt | 444.448 | |
| Formula | C20H24N6O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Diao Y, et al. Oncol Rep. 2016 Feb;35(2):793-800.
2. Du Y, et al. Antiviral Res. 2016 Jul;131:9-18.
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