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SZU-106

Chemical Structure : SZU-106

CAS No.: 2064235-35-2

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SZU-106 (SZU106)

Catalog No.: PC-49146Not For Human Use, Lab Use Only.

SZU-106 is a small molecule TLR7 agonist, selectively activates TLR7 and increases the expression of SEAP by activating the NF-κB pathway.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SZU-106 is a small molecule TLR7 agonist, selectively activates TLR7 and increases the expression of SEAP by activating the NF-κB pathway.
    SZU-106 (0.5-10 μM) increased the release of interferon (IFN)-γ and IL-6 in a dose-dependent manner after 24 h of treatment in mouse splenic lymphocytes.
    SZU-106 with a pegylated linker could produce a novel whole-tumor-cell vaccine, which induced immune-activating responses in both in vitro and in vivo experiments.

    Physicochemical Properties

    M.Wt 603.633
    Formula C27H37N7O9
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(4-((6-amino-8-hydroxy-2-(2-methoxyethoxy)-9H-purin-9-yl)methyl)phenyl)-3,6-dioxo-10,13-dioxa-2,7-diazahexadecan-16-oic acid

    References

    1. Huju Chi, et al. Cells. 2022 Jun 21;11(13):1986.

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