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Chemical Structure : GS-9620
CAS No.: 1228585-88-3
Catalog No.: PC-49254Not For Human Use, Lab Use Only.
Vesatolimod (GS-9620) is a potent and selective orally active small molecule agonist of Toll-like receptor 7 (TLR7) with EC50 of 291 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $158 | In stock | |
| 50 mg | $268 | In stock | |
| 100 mg | $458 | In stock | |
| 1 g | Get quote |
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Vesatolimod (GS-9620) is a potent and selective orally active small molecule agonist of Toll-like receptor 7 (TLR7) with EC50 of 291 nM.
GS-9620 displays a lower minimum effective concentration for IFN-α, chemokines CXCL10 (IP-10), CCL7 (MCP-3), and CCL4 (MIP-1β), IL-1 Receptor Antagonist (IL-1RA), and IFN-γ in comparison to proinflammatory cytokines.
GS-9620 induces durable antiviral efficacy in woodchucks chronically infected with woodchuck hepatitis virus (WHV).
GS-9620 induces HIV in peripheral blood mononuclear cells (PBMCs) from HIV-infected individuals on suppressive antiretroviral therapy.
| M.Wt | 410.522 | |
| Formula | C22H30N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-amino-2-butoxy-7,8-dihydro-8-[[3-(1-pyrrolidinylmethyl)phenyl]methyl]-6(5H)-pteridinone |
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1. Roethle PA, et al. J Med Chem. 2013 Sep 26;56(18):7324-33.
2. Lanford RE, et al. Gastroenterology. 2013 Jun;144(7):1508-17, 1517.e1-10.
3. Gane EJ, et al. J Hepatol. 2015 Aug;63(2):320-8.
4. Tsai A, et al. J Virol. 2017 Mar 29;91(8):e02166-16.
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