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AZD8848

Chemical Structure : AZD8848

CAS No.: 866269-28-5

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AZD8848 (AZD-8848)

Catalog No.: PC-20229Not For Human Use, Lab Use Only.

AZD8848 (AZD 8848) is a potent, selective TLR7 agonist with EC50 of 4 nM for induction of IFNα from human PBMCs and an IC50 of 0.2-1.0 nM for inhibition of IL-5.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AZD8848 (AZD 8848) is a potent, selective TLR7 agonist with EC50 of 4 nM for induction of IFNα from human PBMCs and an IC50 of 0.2-1.0 nM for inhibition of IL-5.
    AZD8848 has no activity against human TLR8 or against any of the other human TLRs.
    AZD8848 is efficacious at reducing OVA-induced inflammation in the lung in the Brown Norway rat model.

    Physicochemical Properties

    M.Wt 569.71
    Formula C29H43N7O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    methyl 2-(3-(((3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl)(3-morpholinopropyl)amino)methyl)phenyl)acetate

    References

    1. Greiff L, et al. Respir Res. 2012 Jun 22;13(1):53.

    2. Delaney S, et al. BMJ Open Respir Res. 2016 Feb 23;3(1):e000113.

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