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Chemical Structure : E567
Catalog No.: PC-49127Not For Human Use, Lab Use Only.
E567 is a small moleculeTLR2 signaling inhibitor with anti-viral activity, efficiently inhibits both LCMV and HSV-1 induced cytokine responses in both human and mouse cell cultures.
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E567 is a small moleculeTLR2 signaling inhibitor with anti-viral activity, efficiently inhibits both LCMV and HSV-1 induced cytokine responses in both human and mouse cell cultures.
E567 down-regulates TLR2 expression, and blocks LCMV-induced TLR2-mediated NF-κB activity and production of IL-8 in HEK cells, does not affect TNF-α-induced expression of TLR2.
E567 inhibits LCMV-induced TLR2 expression and LCMV replication in HEK293 cells.
E567 inhibits both LCMV and HSV induced cytokine responses in primary mouse macrophages.
E567 inhibits both LCMV and HSV-1-induced RANTES and IL8 production in mouse primary macrophages.
E567 (16 mg/kg) blocks LCMV and other TLR ligands induced inflammation, also significantly blocks both TLR2 ligand Pam2CSK4 and TLR4 ligand LPS induced IL-6 and MCP-1 production in vivo.
| M.Wt | 378.476 | |
| Formula | C22H26N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shenghua Zhou, et al. Antiviral Res. 2010 Sep;87(3):295-306.
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