TL8-506 | TLR8 agonist | Probechem Biochemicals

Chemical Structure : TL8-506

TL8-506 (TL 8-506 )

Catalog No.: PC-20228Not For Human Use, Lab Use Only.

TL8-506 is a potent, selective TLR8 agonist with EC50 of 30 nM for inducing NF-κB activation in TLR8-transfeceted HEK293 cells.

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Biological Activity

TL8-506 is a potent, selective TLR8 agonist with EC50 of 30 nM for inducing NF-κB activation in TLR8-transfeceted HEK293 cells.
TL8-506 is also a TLR8 ligand more potent than resiquimod and 3M-002.

Physicochemical Properties

M.Wt	331.38
Formula	C20H17N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 2-amino-8-(3-cyanophenyl)-3H-benzo[b]azepine-4-carboxylate

References

1. Cindy Patinote, et al. Eur J Med Chem. 2020 May 1; 193: 112238.

2. Patra MC, et al. Cells. 2020 Jul 9;9(7):1648.

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TL8-506 (TL 8-506 )

Biological Activity

Physicochemical Properties

References

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