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TL8-506

Chemical Structure : TL8-506

CAS No.: 1268163-15-0

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TL8-506 (TL 8-506 )

Catalog No.: PC-20228Not For Human Use, Lab Use Only.

TL8-506 is a potent, selective TLR8 agonist with EC50 of 30 nM for inducing NF-κB activation in TLR8-transfeceted HEK293 cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TL8-506 is a potent, selective TLR8 agonist with EC50 of 30 nM for inducing NF-κB activation in TLR8-transfeceted HEK293 cells.
    TL8-506 is also a TLR8 ligand more potent than resiquimod and 3M-002.

    Physicochemical Properties

    M.Wt 331.38
    Formula C20H17N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ethyl 2-amino-8-(3-cyanophenyl)-3H-benzo[b]azepine-4-carboxylate

    References

    1. Cindy Patinote, et al. Eur J Med Chem. 2020 May 1; 193: 112238.

    2. Patra MC, et al. Cells. 2020 Jul 9;9(7):1648.

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