Catalog No.: PC-20180Not For Human Use, Lab Use Only.
TLR3/dsRNA Complex Inhibitor (CU-CPT4a, TLR3i) is a specific small molecule inhibitor targeting the dsRNA binding region of TLR3 with Ki of 2.96 uM, blocks Poly (I:C)-induced TLR3 activation with IC50 of 3.44 uM.
TLR3/dsRNA Complex Inhibitor (CU-CPT4a, TLR3i) is a specific small molecule inhibitor targeting the dsRNA binding region of TLR3 with Ki of 2.96 uM, blocks Poly (I:C)-induced TLR3 activation with IC50 of 3.44 uM.
TLR3/dsRNA Complex Inhibitor (TLR3i) inhibits TLR3 signaling without affecting other TLRs (TLR1/2, TLR2/6, TLR3, TLR4, and TLR7).
TLR3/dsRNA Complex Inhibitor disrupts the TLR3/dsRNA association by directly targeting the RNA-binding site on TLR3.
TLR3/dsRNA Complex Inhibitor also inhibits the downstream signaling transduction mediated by the formation of the TLR3/dsRNA complex. TLR3/dsRNA Complex Inhibitor abolishes the TNF-α and IL-1β production activated by 15 µg/ml Poly (I:C) in the RAW 264.7 cells with IC90 of 27 uM.
