ER-899742 | TLR7/8 antagonist | Probechem Biochemicals

Chemical Structure : ER-899742

Catalog No.: PC-27775Not For Human Use, Lab Use Only.

ER-899742 is a potent, selective dual antagonist of TLR7/8 with IC50 of 15/16 nM for hTLR7/8 respectively, with no activity against hTLR9.

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Biological Activity

ER-899742 is a potent, selective dual antagonist of TLR7/8 with IC50 of 15/16 nM for hTLR7/8 respectively, with no activity against hTLR9.

M.Wt	383.43
Formula	C20H22FN5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,6R)-4-(8-cyanoquinolin-5-yl)-N-((3R,4S)-4-fluoropyrrolidin-3-yl)-6-methylmorpholine-2-carboxamide

1. Patent US20150105370 A1 2015-04-16.

2. Zhang Z, et al. J Med Chem. 2026 Aug 13;69(15):18665-18691.