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SMU-H1

Chemical Structure : SMU-H1

CAS No.: 2410782-67-9

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SMU-H1

Catalog No.: PC-28572Not For Human Use, Lab Use Only.

SMU-H1 is a potent, selective TLR2 agonist with EC50 of 5.14 nM, binds TLR2 to recruit MyD88, activates the MAPK/NF-κB pathways, and induces proinflammatory cytokines.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SMU-H1 is a potent, selective TLR2 agonist with EC50 of 5.14 nM, binds TLR2 to recruit MyD88, activates the MAPK/NF-κB pathways, and induces proinflammatory cytokines.
SMU-H1 shows negligible effect using HEK-Blue TLR reporter cell lines expressing hTLR3, hTLR4, hTLR7, or hTLR8.
SMU-H1 drives M1 macrophage polarization and dendritic cell activation via TLR2.
SMU-H1 enhanced immune cell activation and improved antitumor efficacy when combined with conventional anticancer drugs in vivo.

Physicochemical Properties

M.Wt 411.40
Formula C18H16F3N3O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(1-(2-(Methylamino)-5-(methylsulfonyl)phenyl)-1H-imidazole-4-yl)-5-(trifluoromethyl)phenol

References

1. Yue Pan, et al. J Med Chem. 2026 Sep 24;69(18):21483-21504.

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