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INI-4001

Chemical Structure : INI-4001

CAS No.: 2549050-07-7

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INI-4001

Catalog No.: PC-27719Not For Human Use, Lab Use Only.

INI-4001 is a selective, synthetic TLR7/8 agonist with EC50 of 1.89/4.86 uM, regulates innate and adaptive immune responses, acts as a vaccine adjuvant.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

INI-4001 is a selective, synthetic TLR7/8 agonist with EC50 of 1.89/4.86 uM, regulates innate and adaptive immune responses, acts as a vaccine adjuvant.
INI-4001 enhances IgG and neutralizing antibody responses against Powassan virus (POWV), reduces viral loads in the brain, liver and spleen, provides complete protection against lethal POWV challenge, and skews immune responses toward a Th1 phenotype.

Physicochemical Properties

M.Wt 1141.52
Formula C59H109N6O13P
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2S)-3-(2-(2-(2-(((2-(4-((6-amino-8-oxo-2-(((S)-pentan-2-yl)oxy)-7,8-dihydro-9H-purin-9-yl)methyl)piperidin-1-yl)ethoxy)(hydroxy)phosphoryl)oxy)ethoxy)ethoxy)ethoxy)propane-1,2-diyl dipalmitate

References

1. Miller SM, et al. NPJ Vaccines. 2023 Jul 10;8(1):97.

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