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Telratolimod

Chemical Structure : Telratolimod

CAS No.: 1359993-59-1

Telratolimod (MEDI 9197;3M 052)

Catalog No.: PC-61400Not For Human Use, Lab Use Only.

Telratolimod (MEDI 9197, 3M 052) is a novel, injectable, tissue-retained TLR7/8 agonist that forms a tissue depot with gradual, sustained release, allowing local TLR triggering activity without systemic cytokine release.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Telratolimod (MEDI 9197, 3M 052) is a novel, injectable, tissue-retained TLR7/8 agonist that forms a tissue depot with gradual, sustained release, allowing local TLR triggering activity without systemic cytokine release.
Telratolimod (MEDI 9197, 3M 052) induces local innate immune activation as well as systemic, antigen-specific CD8+ T cell responses which suppressed distant, uninjected tumors; is currently under clinical development for use in vaccines and cancer therapy.

Physicochemical Properties

M.Wt 593.901
Formula C36H59N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-{4-[(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)oxy]butyl}octadecanamide

References

1. Singh M, et al. J Immunol. 2014 Nov 1;193(9):4722-31.

2. Van Hoeven N, et al. Sci Rep. 2017 Apr 21;7:46426.

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