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Isatoribine

Chemical Structure : Isatoribine

CAS No.: 122970-40-5

Isatoribine (ANA245;7-Thia-8-oxoguanosine;Immunosine)

Catalog No.: PC-62779Not For Human Use, Lab Use Only.

Isatoribine (ANA245; 7-Thia-8-oxoguanosine; Immunosine) is a nucleoside analogue, selective agonist of TLR7 with significant antiviral effect and mmunoenhancing activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Isatoribine (ANA245; 7-Thia-8-oxoguanosine; Immunosine) is a nucleoside analogue, selective agonist of TLR7 with significant antiviral effect and mmunoenhancing activity.
    Isatoribine (ANA245) stimulates proliferation of thymocytes in vitro, stimulates IL-2 production and the expression of activation markers (CD25 and CD71).
    Isatoribine (ANA245) reduces plasma virus concentration in chronic HCV infection。
    Isatoribine (ANA245) also increase the efficacy of a weakly immunogenic murine L1210 leukemia vaccine in vivo.

    Physicochemical Properties

    M.Wt 316.288
    Formula C10H12N4O6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    5-amino-3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4H-[1,3]thiazolo[4,5-d]pyrimidine-2,7-dione

    References

    1. Horsmans Y, et al. Hepatology. 2005 Sep;42(3):724-31.

    2. Smee DF, et al. Antiviral Res. 1991 Mar-Apr;15(3):229-39.

    3. Jin A, et al. Cell Immunol. 1990 Apr 1;126(2):414-9.

    4. Sharma BS, et al. Cancer Immunol Immunother. 1991;33(2):109-14.

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