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Chemical Structure : 1Z105
Catalog No.: PC-70318Not For Human Use, Lab Use Only.
1Z105 is a novel synthetic, orally bioavailable TLR4/MD2 ligand, significantly reduces the IL-6 secretion by subsequent challenge with LPS at 0.63 uM.
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1Z105 is a novel synthetic, orally bioavailable TLR4/MD2 ligand, significantly reduces the IL-6 secretion by subsequent challenge with LPS at 0.63 uM.
1Z105 desensitizes cells to subsequent TLR activation.
1Z105 prevents lethal liver damage in LPS treated galatosamine-conditioned mice, also prevents arthritis in an autoantibody-driven murine model.
| M.Wt | 446.569 | |
| Formula | C25H26N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hayashi T, et al. J Pharmacol Exp Ther. 2014 Aug;350(2):330-40.
2. Rajaiah R, et al. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8391-6.
3. Goff PH, et al. J Virol. 2015 Mar;89(6):3221-35.
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