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1Z105

Chemical Structure : 1Z105

CAS No.: 1438280-73-9

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1Z105 (1Z 105)

Catalog No.: PC-70318Not For Human Use, Lab Use Only.

1Z105 is a novel synthetic, orally bioavailable TLR4/MD2 ligand, significantly reduces the IL-6 secretion by subsequent challenge with LPS at 0.63 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    1Z105 is a novel synthetic, orally bioavailable TLR4/MD2 ligand, significantly reduces the IL-6 secretion by subsequent challenge with LPS at 0.63 uM.
    1Z105 desensitizes cells to subsequent TLR activation.
    1Z105 prevents lethal liver damage in LPS treated galatosamine-conditioned mice, also prevents arthritis in an autoantibody-driven murine model.

    Physicochemical Properties

    M.Wt 446.569
    Formula C25H26N4O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-cyclohexyl-2-((5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetamide

    References

    1. Hayashi T, et al. J Pharmacol Exp Ther. 2014 Aug;350(2):330-40.

    2. Rajaiah R, et al. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8391-6.

    3. Goff PH, et al. J Virol. 2015 Mar;89(6):3221-35.

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