KBD4466 | TLR7/8 inhibitor | Probechem Biochemicals

Chemical Structure : KBD4466

KBD4466 (KBD-4466)

Catalog No.: PC-24869Not For Human Use, Lab Use Only.

KBD4466 is a potent, highly selective inhibitor of TLR7/8 with IC50 of 0.9/2.8 nM respectively in HEK293 cellular reporter assays, does not inhibit TLR9.

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Biological Activity

KBD4466 is a potent, highly selective inhibitor of TLR7/8 with IC50 of 0.9/2.8 nM respectively in HEK293 cellular reporter assays, does not inhibit TLR9.

Physicochemical Properties

M.Wt	468.48
Formula	C24H23F3N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((1S,5R)-1-(5-(1-Methylpiperidin-4-yl)-1,3,4-oxadiazol-2-yl)-5-(trifluoromethyl)-3-azabicyclo[3.1.0]hexan-3-yl)quinoline-8-carbonitrile

References

1. Yuan Y, et al. J Med Chem. 2025 Jul 1. doi: 10.1021/acs.jmedchem.5c00656.

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KBD4466 (KBD-4466)

Biological Activity

Physicochemical Properties

References

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