Chemical Structure : TLR7 agonist 20
CAS No.:
2410517-32-5
TLR7 agonist 20
Catalog No.: PC-21750Not For Human Use, Lab Use Only.
TLR7 agonist 20 is a potent, selective TLR7 agonist with EC50 of 12 nM and 17 nM for hTLR and mTLR7 in cell-based reporter assay, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TLR7 agonist 20 is a potent, selective TLR7 agonist with EC50 of 12 nM and 17 nM for hTLR and mTLR7 in cell-based reporter assay, respectively.
TLR7 agonist 20 displays no significant activity against TLR8 (EC50>5 uM).
TLR7 agonist 20 significantly induces secretion of cytokines IL-6, IL-1β, IL-10, TNFa, IFNa, and IP-10 in human and mouse whole blood. shows a significant secretion of IFNα and TNFα cytokines in pharmacokinetic and pharmacodynamic studies in mice.
TLR7 agonist 20 shows strong synergistic antitumor activity with complete tumor regression in 8/10 mice dosed using the intravenous route, when combined with aPD1.
Physicochemical Properties
|
M.Wt
|
483.62
|
|
Formula
|
C25H37N7O3
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(S)-3-((5-amino-1-(2-methoxy-4-(((tetrahydro-2H-pyran-4-yl)amino)methyl)benzyl)-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino)hexan-1-ol
|
References
1. Jayakodiarachchi N, et al. ACS Med Chem Lett. 2024 Jan 19;15(2):302-309.
Contact Us
sales@probechem.com
