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Chemical Structure : TLR7 agonist 20
Catalog No.: PC-21750Not For Human Use, Lab Use Only.
TLR7 agonist 20 is a potent, selective TLR7 agonist with EC50 of 12 nM and 17 nM for hTLR and mTLR7 in cell-based reporter assay, respectively.
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TLR7 agonist 20 is a potent, selective TLR7 agonist with EC50 of 12 nM and 17 nM for hTLR and mTLR7 in cell-based reporter assay, respectively.
TLR7 agonist 20 displays no significant activity against TLR8 (EC50>5 uM).
TLR7 agonist 20 significantly induces secretion of cytokines IL-6, IL-1β, IL-10, TNFa, IFNa, and IP-10 in human and mouse whole blood. shows a significant secretion of IFNα and TNFα cytokines in pharmacokinetic and pharmacodynamic studies in mice.
TLR7 agonist 20 shows strong synergistic antitumor activity with complete tumor regression in 8/10 mice dosed using the intravenous route, when combined with aPD1.
| M.Wt | 483.62 | |
| Formula | C25H37N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jayakodiarachchi N, et al. ACS Med Chem Lett. 2024 Jan 19;15(2):302-309.
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