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Chemical Structure : Neoseptin-3
CAS No.: 1622863-21-1
Catalog No.: PC-20737Not For Human Use, Lab Use Only.
Neoseptin-3 is a specific synthetic agonist of mouse toll-like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD-2) complex, promotes macrophage TNFα production with EC50 of 18.5 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Neoseptin-3 is a specific synthetic agonist of mouse toll-like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD-2) complex, promotes macrophage TNFα production with EC50 of 18.5 uM.
Neoseptin-3 induces TNFα, IL-6, and IFN-β secretion in different mouse cells.
Neoseptin-3 does not require TLR2, TLR3, TLR6, TLR7, or TLR9 to induce TNFα.
Neoseptin-3 specifically engages and activates mouse TLR4/MD-2, but cannot activate human TLR4/MD-2 or mixed heterodimers..
| M.Wt | 474.60 | |
| Formula | C29H34N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
tert-butyl (S)-2-(4-amino-3-(4-hydroxyphenethyl)benzamido)-4-phenylbutanoate |
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1. Wang Y, et al. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E884-93.
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