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You are here:Home-Chemical Inhibitors & Agonists-Immunology/Inflammation-Toll-like Receptor (TLR)-3M-011
3M-011

Chemical Structure : 3M-011

CAS No.: 642473-62-9

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3M-011 (3M011;3M 854A)

Catalog No.: PC-70305Not For Human Use, Lab Use Only.

3M-011 is a potent TLR7/8 agonist and cytokine inducer.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    3M-011 is a potent TLR7/8 agonist and cytokine inducer.
    3M-011 stimulates type I interferon (IFN) and other cytokines such as TNF-alpha, IL-12, and IFN-gamma from rat peripheral blood mononuclear cells.
    3M-011 induces IL-12 and COX-2 expression in mDC from HIV+ and HIV- individuals, and inhibits H3N2 influenza viral replication in the nasal cavity; potentiates NK cytotoxicity, and shows antitumor effects in scid/B6 mice and scid/NOD mice.

    Physicochemical Properties

    M.Wt 391.49
    Formula C18H25N5O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(1-(4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-yl)methanesulfonamide

    References

    1. Martinson JA, et al. Cell Immunol. 2007 Nov-Dec;250(1-2):75-84.

    2. Hammerbeck DM, et al. Antiviral Res. 2007 Jan;73(1):1-11.

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