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Chemical Structure : CU-CPT8m
CAS No.: 125079-83-6
Catalog No.: PC-60002Not For Human Use, Lab Use Only.
CU-CPT8m is a novel potent, selective TLR8 inhibitor with Kd of 220 nM and IC50 of 67 nM, with negligible cytotoxicity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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CU-CPT8m is a novel potent, selective TLR8 inhibitor with Kd of 220 nM and IC50 of 67 nM, with negligible cytotoxicity.
CU-CPT8m shows no effect on TLR1/2/6, TLR3, TLR4, TLR5, TLR7 and TLR9.
CU-CPT8m inhibits R848-induced TNF-α production in the differentiated THP-1 monocytes cells with IC50 of 90 nM, also abolishes the elevation of TNF-α and IL-8 mRNA levels.
CU-CPT8m suppresses the proinflammatory cytokine production in multiple human primary cells derived from different patients.
| M.Wt | 252.277 | |
| Formula | C14H12N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
7-(m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide |
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1. Zhang S, et al. Nat Chem Biol. 2017 Nov 20. doi: 10.1038/nchembio.2518.
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