1’-cyanocytidine

Chemical Structure : 1’-cyanocytidine

Catalog No.: PC-28371Not For Human Use, Lab Use Only.

1'-cyanocytidine (CNC) is a nontoxic, next-generation nucleoside analog that displays submicromolar inhibition of SARS-CoV-2 replication with EC50 of 0.6-2.1 uM, targeting the viral RNA-dependent RNA polymerase (RdRp).

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Biological Activity

Physicochemical Properties

M.Wt	268.23
Formula	C10H12N4O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3R,4S,5R)-2-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile

References

1. Amblard F, et al. Sci Adv. 2025 Oct 3;11(40):eadz5913.

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1’-cyanocytidine

Biological Activity

Physicochemical Properties

References

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