| Cat. No. |
Product Name |
Information |
| PC-27676 |
SRC-1 inhibitor 10
NCOA1 inhibitor, SARS-CoV-2 inhibitor
|
SRC-1 inhibitor 10 is a small molecule SARS-CoV-2 replication inhibitor targeting host lipogenesis, potently inhibits replication of both the prototypic and BA.1 variants with EC50 of 0.9 and 0.5 uM respectively, binds to and promotes degradation of nuclear receptor coactivator 1 (NCOA1, SRC-1). |
| PC-27482 |
Nosidesivir
Viral RdRp inhibitor
|
Nosidesivir (NGP-1) is a prodrug of GS-441524 with potential anti-SARS-CoV-2 activity, and increased lipophilicity, absorption, and bioavailability. |
| PC-25647 |
SARS-CoV-2 NSP14 inhibitor C10
SARS-CoV-2 NSP14 inhibitor
|
SARS-CoV-2 NSP14 inhibitor C10 is a potent, selective non-nucleoside inhibitor of SARS-CoV-2 nonstructural protein 14 (NSP14) with IC50 of 0.34 uM, exhibits potent antiviral activity and reverses NSP14-driven host modulation. |
| PC-24849 |
KCO237
SARS-CoV-2 Nsp15 inhibitor
|
KCO237 is a potent, reversible, non-covalent inhibitor of SARS-CoV-2 Nsp15 endoribonuclease with IC50 of 304 nM, inhibits VERO 6 cell infection with SARS-CoV-2. |
| PC-24641 |
ISM3312
Mpro inhibitor
|
ISM3312 is a potent, irreversible covalent broad-spectrum inhibitor of human coronavirus main protease (Mpro) with IC50 of 14 nM, exhibits potent cellular potency in VeroE6 cell lines with EC50 of 71 nM. |
| PC-24517 |
N-0920
TMPRSS2 inhibitor
|
N-0920 (Cbz-QFR-kt) is highly potent, specific TMPRSS2 inhibitor with IC50 of 350 pM, displays high antiviral potency with IC50 of 0.3 nM and 0.09 nM for SARS-CoV-2 Variants EG.5.1 and JN.1 respectively. |
| PC-24314 |
JNJ-9676
SARS-CoV-2 M protein inhibitor
|
JNJ-9676 is a potent, specific small-molecule inhibitor of SARS-CoV-2 and SARS-CoV, binds to SARS-CoV-2 M protein, reduces SARS-CoV-2 (B1 variant) production of viral RNA with EC50/EC90 of 94/132 nM respectively. |
| PC-24313 |
CIM-834
SARS-CoV-2 M protein inhibitor
|
CIM-834 is a potent, first-in-class, orally efficacious small molecule coronavirus assembly inhibitor, blocks the assembly of SARS-CoV-2, targets the viral membrane (M) protein, inhibits replication of a panel of SARS-CoV-2 isolates with mean EC50 of 112 nM and 84 nM in VeroE6–GFP and A549ACE2+TMPRSS2 cells, respectively. |
| PC-24181 |
Secutrelvir
SARS-CoV-2 3CLPro inhibitor
|
Secutrelvir (S-892216) is a potent, selective, reversible and covalent, oral SARS-CoV-2 3C-like protease (3CLpro) inhibitor with IC50 of 0.665 nM, and antiviral EC50 of 2.48 nM in CPE inhibition assays. |
| PC-24173 |
Ratutrelvir
SARS-CoV-2 Mpro inhibitor
|
Ratutrelvir (Travatrelvir, 83-0060, TRX01) is a potent, selective inhibitor of SARS-CoV-2 main protease Mpro (3CL protease). |
| PC-23632 |
TDI-015051
SARS-CoV-2 NSP14 inhibitor
|
TDI-015051 is a highly potent, specific inhibitor of SARS-CoV-2 NSP14 RNA cap methyltransferase with Kd of 61 pM and IC50 of <0.15 nM, inhibits viral mRNA translation. |
| PC-23359 |
SHEN26
SARS-CoV-2 RdRp inhibitor
|
Losudesivir (SHEN26, ATV014) is a potent, orally active anti-SARS-CoV-2 nucleoside compound with EC50 of 0.48 uM against SARS-CoV-2 replicon, inhibits SARS-CoV-2 RdRp. |
