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ID3-77

Chemical Structure : ID3-77

CAS No.:

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ID3-77

Catalog No.: PC-28154Not For Human Use, Lab Use Only.

ID3-77 is a potent, covalent inhibitor of SARS-CoV-2 papain-like protease (PLpro) with IC50 of 209 nM, produces strong antiviral effect, reducing viral titer by 5.48 and 5.50 log units at 1 and 10 uM, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ID3-77 is a potent, covalent inhibitor of SARS-CoV-2 papain-like protease (PLpro) with IC50 of 209 nM, produces strong antiviral effect, reducing viral titer by 5.48 and 5.50 log units at 1 and 10 uM, respectively.
ID3-77 covalently labels catalytic Cys111 of PLpro.
ID3-77 shows selectivity over the cysteine proteases cathepsin B and calpain 1.
ID3-77 reduces SARS-CoV-2 lung viral load in vivo.

Physicochemical Properties

M.Wt 475.97
Formula C27H26ClN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-(3-((2-((3-chloroprop-2-yn-1-yl)amino)-2-oxoethyl)amino)-3-oxopropyl)-N-(1-(naphthalen-1-yl)ethyl)benzamide

References

1. Indukuri D, et al. Bioorg Med Chem. 2026 Aug 29;143:118792.

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