| Cat. No. |
Product Name |
Information |
| PC-26476 |
pan-Coronavirus fusion inhibitor EK1
Coronaviruses fusion inhibitor
|
EK1 is a peptide-based fusion inhibitor of coronaviruses (CoVs) with broad spectrum inhibition to a number of CoV species, potently inhibits SARS-CoV-2, competitively binds to heptad repeat 1 in the spike protein, blocking the formation of the six-helix bundle (6-HB) between viral HR1 and HR2 regions required for viral-cellular membrane fusion. |
| PC-26474 |
FD3-32
SARS-CoV-2 Mpro inhibitor
|
FD3-32 is a potent, selective peptidomimetic inhibitor of SARS-CoV-2 main protease (Mpro) with Ki of 0.513 nM (Mpro WT) and 2.18 nM (M49L/E166A mutant). |
| PC-26448 |
Limnetrelvir
SARS-CoV-2 Mpro inhibitor
|
Limnetrelvir (ABBV-903) is a potent, selective SARS-CoV-2 main proteinase (MPro) inhibitor. |
| PC-26443 |
XR8-24
SARS-CoV-2 PLpro inhibitor
|
XR8-24 is a potent, selective SARS-CoV-2 papain-like protease (PLpro) inhibitor with IC50 of 0.56 uM and binding KD of 0.37 uM. |
| PC-26442 |
MR1-114
SARS-CoV-2 PLpro inhibitor
|
MR1-114 is a potent, noncovalent SARS-CoV-2 papain-like protease (PLpro) inhibitor with enzyme IC50 of 37 nM. |
| PC-26441 |
PLpro inhibitor compound 7
SARS-CoV-2 PLpro inhibitor
|
PLpro inhibitor compound 7 is a potent, selective and covalent SARS-CoV-2 papain-like protease (PLpro) inhibitor with IC50 of 94 nM and EC50 of 1.1 uM in SARS-CoV-2-infected Vero E6 cells |
| PC-26440 |
PLP_Snyder530
SARS-CoV-2 PLpro inhibitor
|
PLP_Snyder530 is a potent, selective SARS-CoV-2 papain-like protease (PLpro) inhibitor with IC50 of 6.4 uM. |
| PC-26439 |
XR8-89
SARS-CoV-2 PLpro inhibitor
|
XR8-89 is a potent, selective SARS-CoV-2 papain-like protease (PLpro) inhibitor with IC50 of 0.1 uM. |
| PC-26183 |
AVI-6451
SARS-CoV-2 Mac1 inhibitor
|
AVI-6451 is a potent and selective inhibitor of SARS-CoV-2 ADP-ribosylhydrolase Mac1 with IC50 of 28 nM, ITC Kd of 55 nM. |
| PC-26178 |
GK730
SARS-CoV-2 Mpro inhibitor
|
GK730 is a highly potent, specific SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 5.75 nM, weakly inhibits cathepsin L and does not inhibit cathepsin B. |
| PC-26050 |
EGT710
SARS-CoV-2 Mpro inhibitor
|
EGT710 (NVP-EGT710) is a potent, selective and oral nonpeptidomimetic reversible covalent SARS-CoV-2 Mpro inhibitor with IC50 of 7 nM, shows cellular potency with IC50 of 11 nM in CPE assay in Vero E6 cells. |
| PC-26027 |
VPC285785
SARS-CoV-2 Mpro inhibitor
|
VPC285785 is a novel covalent inhibitor of the SARS-CoV-2 main protease (Mpro) with IC50 of 0.8 uM, VPC285786 additionally inhibits human cathepsin Lwith IC50 of 4.2 uM. |
