| Cat. No. |
Product Name |
Information |
| PC-23213 |
TL1228
GRP78 inhibitor
|
TL1228 is a small molecule inhibitor of SARS-CoV-2 and its target cells, blocking the recognition of the GRP78 cellular receptor by the viral Spike protein, also is a selective inhibitor of the dihydrofolate reductase (DHFR) type B1. |
| PC-22984 |
PF-07957472
SARS-CoV-2 PLpro inhibitor
|
PF-07957472 is a potent, selective, and orally available SARS-CoV-2 papain-like protease (PLpro) inhibitor with Ki of 2 nM, exhibits cell antiviral potency in Vero E6 cells with EC50 of 147 nM. |
| PC-22983 |
P23E02
Nsp1-SL1 inhibitor
|
P23E02 is a small molecule inhibitor of SARS-CoV-2 viral protein Nsp1-40S ribosomal subunit (stem-loop 1, SL1) interaction with IC50 of 2.26 uM, exhibits antiviral efficacy against various sarbecoviruses. |
| PC-22947 |
AVI-4206
SARS-CoV-2 Mac1 inhibitor
|
AVI-4206 is a potent, specific small molecule inhibitor of SARS-CoV-2 ADP-ribosylhydrolase macrodomain (Mac1) with IC50 of 20 nM in HTRF assays. |
| PC-22709 |
GST-HG171
SARS-CoV-2 3CLPro inhibitor
|
GST-HG171 (Atilotrelvir) is a potent, broad-spectrum, orally bioavailable small-molecule 3C-like (3CL) protease inhibitor, has broad-spectrum activity against different variants of SARS-CoV-2. |
| PC-22611 |
SIMM-036
SARS-CoV-2 PLpro inhibitor
|
SIMM-036 is a specific small molecule SARS-CoV-1 PLpro inhibitor with IC50 of 192.3 nM, inhibits the K63-deubiquitinase activity of SARS-CoV-2 Plpro. |
| PC-22547 |
Virapinib
Macropinocytosis inhibitor
|
Virapinib is a specific inhibitor of macropinocytosis with antiviral activity, limits viral entry by macropinocytosis for several viruses including SARS-CoV-2. |
| PC-22224 |
Mpro61
SARS-CoV-2 Mpro inhibitor
|
Mpro61 is a potent nanomolar inhibitor of SARS-CoV-2 Mpro with IC50 of 44 nM, antiviral EC50 of 80 nM. |
| PC-22009 |
ML2006a4
SARS-CoV-2 Mpro inhibitor
|
ML2006a4 is a highly potent, selective and orally bioavailable SARS-CoV-2 main protease (Mpro) inhibitor with IC50/Ki of 1.05/0.26 nM, shows antiviral EC50 value of 100-120 nM in Huh7.5.1-ACE2-TMPRSS2 cells. |
| PC-21878 |
GC-373
SARS-CoV-2 Mpro inhibitor
|
GC373 is a potent, covalent inhibitor of SARS CoV-2 main protease (MPro) with Kd of 0.15 uM, the reactive aldehyde form of GC376. |
| PC-21803 |
MK-7845
SARS-CoV-2 3CLPro inhibitor
|
MK-7845 is a potent, reversible covalent SARS-CoV-2 3CLPro inhibitor with IC50 of 8.7 nM, inhibits wild-type SARS-CoV-2 3CLPro in SARS-CoV-2 reporter replicon assay in A549 cells with IC50 of 15 nM. |
| PC-21690 |
MDOLL-0229
SARS-CoV-2 Mac1 inhibitor
|
MDOLL-0229 is a selective small molecule inhibitor for SARS-CoV-2 Mac1 with IC50 of 2.1 uM, inhibits coronavirus replication. |
