Chemical Structure : pan-Coronavirus fusion inhibitor EK1
CAS No.:
pan-Coronavirus fusion inhibitor EK1
Catalog No.: PC-26476Not For Human Use, Lab Use Only.
EK1 is a peptide-based fusion inhibitor of coronaviruses (CoVs) with broad spectrum inhibition to a number of CoV species, potently inhibits SARS-CoV-2, competitively binds to heptad repeat 1 in the spike protein, blocking the formation of the six-helix bundle (6-HB) between viral HR1 and HR2 regions required for viral-cellular membrane fusion.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
EK1 is a peptide-based fusion inhibitor of coronaviruses (CoVs) with broad spectrum inhibition to a number of CoV species, potently inhibits SARS-CoV-2, competitively binds to heptad repeat 1 in the spike protein, blocking the formation of the six-helix bundle (6-HB) between viral HR1 and HR2 regions required for viral-cellular membrane fusion.
Physicochemical Properties
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M.Wt
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4331.99
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Formula
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C196H317N43O64S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Ser-Leu-Asp-Gln-Ile-Asn-Val-Thr-Phe-Leu-Asp-Leu-Glu-Tyr-Glu-Met-Lys-Lys-Leu-Glu-Glu-Ala-Ile-Lys-Lys-Leu-Glu-Glu-Ser-Tyr-Ile-Asp-Leu-Lys-Glu-Leu
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References
1. Xiu R, et al. J Virol. 2026 Mar 30:e0007626.
2. Monteiro A, et al. Curr HIV Res. 2021;19(6):465-475.
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