| Cat. No. |
Product Name |
Information |
| PC-49528 |
DMGA
SARS-CoV-2 PLpro inhibitor
|
DMGA is an allosteric and covalent inhibitor of SARS-CoV-2 papain-like protease (SARS-CoV-2 PLpro) with IC50 of 9.4 uM, covalently binds with C270 of the SARS-CoV-2 PLpro. |
| PC-49424 |
Difluorobenztropine
SARS-CoV-2 entry inhibitor
|
Difluorobenztropine (AHN 1-055) is a direct-acting SARS-CoV-2 entry inhibitor that targets the SARS-CoV-2 spike fusion peptide domain. |
| PC-49423 |
TMPRSS2 inhibitor BC-11
TMPRSS2 inhibitor
|
TMPRSS2 inhibitor BC-11 is a specific, covalent transmembrane protease serine 2 (TMPRSS2) inhibitor with IC50 of 1.44 uM in vitro TMPRSS2 enzymatic assay. |
| PC-49342 |
GC-14
SARS-CoV-2 Mpro inhibitor
|
GC-14 is a potent, selective and non-covalent non-peptide SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 0.4 uM, displays excellent selectivity over cathepsins B, F, K, L, and caspase 3 (IC50>50 uM). |
| PC-49335 |
WU-04
SARS-CoV-2 3CLpro inhibitor
|
WU-04 (WPV01) is a highly potent, non-covalent, orally active inhibitor of SARS-CoV-2 3C-like protease (3CLpro) with IC50 of 72 nM, binding Kd of 37 nM. |
| PC-49327 |
KSL-128114
Syntenin inhibitor
|
KSL-128114 (KLS 128114) is a highly potent and metabolically stable peptide inhibitor that binds to the PDZ1 domain of syntenin (KD=0.3 uM), inhibits SARS-CoV-2 infection by blocking the endosomal entry of the virus. |
| PC-49258 |
AB-00011778
SARS-CoV-2 entry inhibitor
|
AB-00011778 is a small molecule inhibitor of SARS-CoV-2 entry and the Spike/ACE2 interaction, inhibits viral replication with EC50 of 250 nM in A549-ACE2 cells, AB-00011778 is equally effective in impairing the S/ACE2 association in the different mutants. |
| PC-49191 |
SARS-CoV-2 PLpro inhibitor 7
PLpro inhibitor
|
SARS-CoV-2 PLpro inhibitor 7 is a potent, selective and covalent inhibitor of SARS-CoV-2 papain-like protease (PLpro) with IC50 of 94 nM, shows SARS-CoV-2 antiviral activity with EC50 of 1.1 uM. |
| PC-49155 |
FOY-251
TMPRSS2 inhibitor
|
FOY-251 is a camostat metabolite and inhibitor of TMPRSS2 protease activity with IC50 of 33.3 nM, completely suppresses TMPRSS2 activity at 1 uM, inhibit SARS-2-S-driven cell entry with comparable efficiency (EC50=178 nM) with camostat mesylate. |
| PC-49140 |
JMX0286
SARS-CoV-2 3CLPro inhibitor
|
JMX0286 is a potent, specific and allosteric inhibitor against SARS-CoV-2 3CLpro with IC50 of 4.8 uM in FRET based screening assays, shows strong inhibition of SARS-CoV-2 virus with EC50 of 2.25 uM in A549-hACE2 cells. |
| PC-49052 |
Z8539_0072
SARS-CoV-2 Nsp3 inhibitor
|
Z8539_0072 is a potent SARS-CoV-2 macrodomain inhibitor that binds to the NSP3 macrodomain of SARS-CoV-2 (Mac1) with IC50 of 460 nM. |
| PC-47067 |
RI173
SARS-CoV-2 inhibitor
|
RI173 is a potent, covalent, triple-acting inhibitor of SARS-CoV-2 protease Mpro, PLpro and human cathepsin L with IC50 of 0.6 uM, 0.2 uM and 1.7 uM, respectively. |
