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WNN2048-F004

Chemical Structure : WNN2048-F004

CAS No.: 353257-76-8

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WNN2048-F004 (Compound 4a)

Catalog No.: PC-49668Not For Human Use, Lab Use Only.

WNN2048-F004 (Compound 4a) is a potent, covalent, nonpeptidomimetic SARS-CoV-2 main protease (Mpro) inhibitor with biochemical IC50 of 103 nM, covalently binds to the substrate-binding pocket (Cys145) of SARS-CoV-2 Mpro.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    WNN2048-F004 (Compound 4a) is a potent, covalent, nonpeptidomimetic SARS-CoV-2 main protease (Mpro) inhibitor with biochemical IC50 of 103 nM, covalently binds to the substrate-binding pocket (Cys145) of SARS-CoV-2 Mpro.
    WNN2048-F004 showed good anti-SARS-CoV-2 infection activity in cell culture with IC50 value of 21.3 µmol/L without cytotoxicity effect.

    Physicochemical Properties

    M.Wt 274.12
    Formula C10H5Cl2NO2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-chloropyridin-3-yl 3-chlorothiophene-2-carboxylate

    References

    1. Zang Y, et al. Protein Cell. 2022 Sep 28;14(1):17-27.

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