| Cat. No. |
Product Name |
Information |
| PC-49155 |
FOY-251
TMPRSS2 inhibitor
|
FOY-251 is a camostat metabolite and inhibitor of TMPRSS2 protease activity with IC50 of 33.3 nM, completely suppresses TMPRSS2 activity at 1 uM, inhibit SARS-2-S-driven cell entry with comparable efficiency (EC50=178 nM) with camostat mesylate. |
| PC-49140 |
JMX0286
SARS-CoV-2 3CLPro inhibitor
|
JMX0286 is a potent, specific and allosteric inhibitor against SARS-CoV-2 3CLpro with IC50 of 4.8 uM in FRET based screening assays, shows strong inhibition of SARS-CoV-2 virus with EC50 of 2.25 uM in A549-hACE2 cells. |
| PC-49052 |
Z8539_0072
SARS-CoV-2 Nsp3 inhibitor
|
Z8539_0072 is a potent SARS-CoV-2 macrodomain inhibitor that binds to the NSP3 macrodomain of SARS-CoV-2 (Mac1) with IC50 of 460 nM. |
| PC-47067 |
RI173
SARS-CoV-2 inhibitor
|
RI173 is a potent, covalent, triple-acting inhibitor of SARS-CoV-2 protease Mpro, PLpro and human cathepsin L with IC50 of 0.6 uM, 0.2 uM and 1.7 uM, respectively. |
| PC-47020 |
Nafamostat mesylate
SARS-CoV-2 Inhibitor
|
Nafamostat mesylate (FUT-175) is a synthetic serine protease inhibitor with anticoagulant, anti-inflammatory, mucus clearing, and potential antiviral activities, blocks SARS-CoV-2 infection of Calu-3 cells with IC50 of 10 nM. |
| PC-38897 |
VE607
SARS-CoV entry inhibitor
|
VE607 is a specific small molecule inhibitor that block S protein-ACE2-mediated cellular entry of the SARS-CoV, inhibits pseudovirus entry with EC50 of 3 μM and inhibited SARS-CoV plaque formation with EC50 of 1.6 μM. |
| PC-38735 |
VV116
SARS-CoV-2 inhibitor
|
VV116 (Mindeudesivir, JT001) is a promising orally active remdesivir derivative against SARS-CoV-2, targeting the viral RNA-dependent RNA polymerase through its nucleoside triphosphate form with IC50 of 0.67 uM. |
| PC-38696 |
Y180
SARS-CoV-2 Mpro inhibitor
|
Y180 is a highly potent, selective, covalent, and orally active SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 8.1 nM in enzymatic assays, binding Ki value of 1 nM. |
| PC-38568 |
SSAA09E3
SARS CoV entry inhibitor
|
SSAA09E3 is a small molecule inhibitor of SARS coronavirus with EC50 of 0.15 uM in infectious virus assay in Vero cells, preventing fusion of the viral membrane with the host cellular membrane. |
| PC-38498 |
SARS-CoV-2 nsp14 inhibitor 25
SARS-CoV-2 nsp14 inhibitor
|
SARS-CoV-2 nsp14 inhibitor 25 is a highly potent, selective, nucleoside-derived inhibitor of SARS-CoV-2 nsp14 (N7-guanine)-methyltransferase (N7-MTase) with IC50 of 19 nM, no inhibition against human RNA N7-MTase (hRNMT, IC50>50 uM). |
| PC-38459 |
GS-621763
SARS-CoV-2 Inhibitor
|
GS-621763 is an oral prodrug of remdesivir parent nucleoside GS-441524, inhibits SARS-CoV-2, including variants of concern in cell culture (EC50=0.11 to 0.73 uM) and human airway epithelium organoids. |
| PC-73461 |
Molnupiravir
SARS-CoV-2 inhibitor
|
EIDD-2801 (MK-4482, Molnupiravir) is a highly potent ribonucleoside analog, and prodrug of EIDD-1931, exhibits broad-spectrum antiviral inhibitor of multiple RNA viruses including SARS-CoV-2. |
