| Cat. No. |
Product Name |
Information |
| PC-21479 |
JC19
SARS-CoV-2 nsp14 degrader
|
JC19 is a a cysteine-reactive small molecule degrader of SARS-CoV-2 nsp14 with DC50 of 8.7 uM in HEK293T cells. |
| PC-21450 |
FB2001
SARS-CoV-2 Mpro inhibitor
|
Bofutrelvir (FB2001) is a potent, selective and covalent SARS-CoV-2 main protease (Mpro) inhibitor with IC50 value of 53 nM. |
| PC-21335 |
MAT-POS-e194df51-1
SARS-CoV-2 Mpro inhibitor
|
MAT-POS-e194df51-1 is potent, selective and noncovalent SARS-CoV-2 main protease (SARS-CoV-2 Mpro) inhibitor with IC50 of 36.8 nM, shows antiviral activity with EC50 of 64 nM in A549-ACE2-TMPRSS2 cells. |
| PC-21248 |
Pomotrelvir
SARS-CoV-2 Mpro inhibitor
|
Pomotrelvir (PBI-0451) is a potent competitive inhibitor of SARS-CoV-2 Mpro (Ki=2.7 nM) with high selectivity against human proteases, inhibits wild-type SARS-CoV-2 Mpro with IC50 of 24 nM. |
| PC-21243 |
Simnotrelvir
SARS-CoV-2 3CLpro inhibitor
|
Simnotrelvir (SSD8432, SIM0417) is a potent, selective, covalent and orally bioavailable SARS-CoV-2 3C-like protease (3CLpro) inhibitor with IC50 of 9 nM in enzymatic inhibition assays. |
| PC-21077 |
GS-441524
Viral RdRp inhibitor
|
GS-441524 (GS441524) is the active metabolite of Remdesivir, inhibits viral RNA dependent RNA polymerase (RdRp) from the Flaviviridae family including SARS-CoV-2. |
| PC-21075 |
Obeldesivir
SARS-CoV-2 inhibitor
|
Obeldesivir (GS-5245, ATV006) is an orall bioavailable, 5'-isobutyryl ester prodrug of GS-441524, exhibits strong SARS-CoV-2 antiviral efficacy both in vitro and in vivo. |
| PC-21016 |
SARS-CoV-2 3CLpro inhibitor C5a
SARS-CoV-2 3CLpro inhibitor
|
SARS-CoV-2 3CLpro inhibitor C5a is a potent, non-covalent, non-peptide inhibitor of 3C-like protease (3CLpro) inhibitor with dissociation constant (Kd) of 170 nM, IC50 of 0.7 uM against recombinant SARS-CoV-2 3CLpro. |
| PC-20951 |
NACE2i
ACE2 inhibitor
|
NACE2i is a cell permeable, specific and selective peptide inhibitor of nuclear ACE2, inhibits binding between IMP1α and ACE2 and SARS-CoV-2 viral replication. |
| PC-49865 |
TKB248
SARS-CoV-2 Mpro inhibitor
|
TKB248 (TKB-248) is a potent, specific SARS-CoV-2 Mpro inhibitor with IC50 of 74 nM, exhibits highly potent anti-SARS-CoV-2 activity with EC50 and EC95 values of 0.22 and 0.87 µM, respectively. |
| PC-49864 |
TKB245
SARS-CoV-2 Mpro inhibitor
|
TKB245 (TKB-245) is a potent, specific SARS-CoV-2 Mpro inhibitor with IC50 of 7 nM, exhibits highly potent anti-SARS-CoV-2 activity with EC50 and EC95 values of 0.03 and 0.53 µM, respectively. |
| PC-49668 |
WNN2048-F004
SARS-CoV-2 Mpro inhibitor
|
WNN2048-F004 (Compound 4a) is a potent, covalent, nonpeptidomimetic SARS-CoV-2 main protease (Mpro) inhibitor with biochemical IC50 of 103 nM, covalently binds to the substrate-binding pocket (Cys145) of SARS-CoV-2 Mpro. |
