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Chemical Structure : TMPRSS2 inhibitor BC-11
Catalog No.: PC-49423Not For Human Use, Lab Use Only.
TMPRSS2 inhibitor BC-11 is a specific, covalent transmembrane protease serine 2 (TMPRSS2) inhibitor with IC50 of 1.44 uM in vitro TMPRSS2 enzymatic assay.
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TMPRSS2 inhibitor BC-11 is a specific, covalent transmembrane protease serine 2 (TMPRSS2) inhibitor with IC50 of 1.44 uM in vitro TMPRSS2 enzymatic assay.
BC-11 is inactive against three proteases (furin, CATSB, and CATSL).
BC-11 showed modest inhibition of SARS-CoV-2 entry with EC50 of 66 uM.
A combination of the direct- and indirect-acting antivirals (BC-11 and AHN 1-055) demonstrated better viral entry inhibition than either compound alone.
| M.Wt | 210.058 | |
| Formula | C8H11BN2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Moumbock AFA, et al. Arch Pharm (Weinheim). 2022 Oct 31:e2200371.
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