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TMPRSS2 inhibitor BC-11

Chemical Structure : TMPRSS2 inhibitor BC-11

CAS No.: 770703-09-8

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TMPRSS2 inhibitor BC-11

Catalog No.: PC-49423Not For Human Use, Lab Use Only.

TMPRSS2 inhibitor BC-11 is a specific, covalent transmembrane protease serine 2 (TMPRSS2) inhibitor with IC50 of 1.44 uM in vitro TMPRSS2 enzymatic assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TMPRSS2 inhibitor BC-11 is a specific, covalent transmembrane protease serine 2 (TMPRSS2) inhibitor with IC50 of 1.44 uM in vitro TMPRSS2 enzymatic assay.
    BC-11 is inactive against three proteases (furin, CATSB, and CATSL).
    BC-11 showed modest inhibition of SARS-CoV-2 entry with EC50 of 66 uM.
    A combination of the direct- and indirect-acting antivirals (BC-11 and AHN 1-055) demonstrated better viral entry inhibition than either compound alone.

    Physicochemical Properties

    M.Wt 210.058
    Formula C8H11BN2O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4-((carbamimidoylthio)methyl)phenyl)boronic acid

    References

    1. Moumbock AFA, et al. Arch Pharm (Weinheim). 2022 Oct 31:e2200371.

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